Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
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Mechanisms of divalent metal toxicity in affective disordersQuantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugsIron and cancer: more ore to be mined.Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1.Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxiaDp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.Iron chelation: a potential therapeutic strategy in oesophageal cancer.Iron depletion enhances the effect of sorafenib in hepatocarcinomaThe novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.Iron chelation in the treatment of cancer: a new role for deferasirox?The role of NDRG1 in the pathology and potential treatment of human cancers.Regulation of cellular iron metabolism and its implications in lung cancer progression.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity.The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism.Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.Piperazinyl fragment improves anticancer activity of Triapine.In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma.Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine ,-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of mechanisms of actionEffects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism
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P2860
Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@ast
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@en
type
label
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@ast
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@en
prefLabel
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@ast
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@en
P2093
P2860
P1476
Bp44mT: an orally active iron ...... h potent anti-tumour efficacy.
@en
P2093
D R Richardson
Y Suryo Rahmanto
P2860
P304
P356
10.1111/J.1476-5381.2011.01526.X
P407
P577
2012-01-01T00:00:00Z