Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.
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Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptorGenetic Models for the Study of Luteinizing Hormone Receptor FunctionPrecocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsBicalutamide and third-generation aromatase inhibitors in testotoxicosisThe formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor.Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinasesPotential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).Clinical and molecular analysis of human reproductive disorders in Brazilian patients.Revisiting and questioning functional rescue between dimerized LH receptor mutants.Structure, function and regulation of gonadotropin receptors - a perspective.LH receptor gene expression in cumulus cells in women entering an ART program.Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.The role of chorionic gonadotropin and Notch1 in implantation.An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.Perspectives in Pediatric Pathology, Chapter 15. Macrorchidism as the Expression of Several Congenital and Acquired Pathologies.Reduced cell surface expression of CCR5 in CCR5Delta 32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration.Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.Mother-to-son transmission of a luteinizing hormone receptor activating mutation in a prepubertal child with testotoxicosis.Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole.Constitutive luteinizing hormone receptor signaling causes sexual dysfunction and Leydig cell adenomas in male mice.Hipoplasia das células de LeydigGenética molecular do eixo hipotálamo-hipófise-gonadalAspectos Moleculares da Determinação e Diferenciação Sexual
P2860
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P2860
Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Naturally occurring mutations ...... d G protein-coupled receptors.
@ast
Naturally occurring mutations ...... d G protein-coupled receptors.
@en
type
label
Naturally occurring mutations ...... d G protein-coupled receptors.
@ast
Naturally occurring mutations ...... d G protein-coupled receptors.
@en
prefLabel
Naturally occurring mutations ...... d G protein-coupled receptors.
@ast
Naturally occurring mutations ...... d G protein-coupled receptors.
@en
P2860
P356
P1476
Naturally occurring mutations ...... nd G protein-coupled receptors
@en
P2093
D L Segaloff
P2860
P304
P356
10.1086/302602
P407
P577
1999-10-01T00:00:00Z