G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
about
Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in AsthmaPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12The actin-bundling protein L-plastin supports T-cell motility and activationTurning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug developmentRhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cellsSolute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo.A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cellsCooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.A directional switch of integrin signalling and a new anti-thrombotic strategy.Targeting integrin and integrin signaling in treating thrombosis.Platelets and infection - an emerging role of platelets in viral infection.Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factorG(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptorsCB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.Paired immunoglobulin-like receptor B regulates platelet activation.Integrin αIIb-mediated PI3K/Akt activation in platelets.Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.Signaling during platelet adhesion and activationConformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesNegative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.Multiscale simulations suggest a mechanism for integrin inside-out activation.Historical perspective and future directions in platelet research.An important role for Akt3 in platelet activation and thrombosisIntegrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells.Platelets Proteomic Profiles of Acute Ischemic Stroke Patients.Integrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinGα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets.RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in PlateletsThe interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoAFocal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.
P2860
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P2860
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@ast
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@en
type
label
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@ast
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@en
prefLabel
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@ast
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@en
P2093
P2860
P356
P1433
P1476
G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling
@en
P2093
Christina Chow
Haixia Gong
Panagiotis Flevaris
Stephen C-T Lam
Tatyana A Voyno-Yasenetskaya
Tohru Kozasa
Xiaoping Du
P2860
P304
P356
10.1126/SCIENCE.1174779
P407
P577
2010-01-01T00:00:00Z