Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line
about
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/KreislerStructure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragmentRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblastsA senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationInsulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cellsExpression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells.Thrombopoietin.Molecular control of megakaryopoiesis and thrombopoiesis.New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura.An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominanceTranscriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells.Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysSTAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells.The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation.Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling.Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2.GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.NF-kappaB family proteins participate in multiple steps of hematopoiesis through elimination of reactive oxygen species.Signaling by the Mpl receptor involves IKK and NF-kappaB.Stromal inhibition of megakaryocytic differentiation correlates with blockade of signaling by protein kinase C-epsilon and ERK/MAPK.Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells.
P2860
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P2860
Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Involvement of prolonged ras a ...... endent hematopoietic cell line
@ast
Involvement of prolonged ras a ...... endent hematopoietic cell line
@en
type
label
Involvement of prolonged ras a ...... endent hematopoietic cell line
@ast
Involvement of prolonged ras a ...... endent hematopoietic cell line
@en
prefLabel
Involvement of prolonged ras a ...... endent hematopoietic cell line
@ast
Involvement of prolonged ras a ...... endent hematopoietic cell line
@en
P2093
P2860
P356
P1476
Involvement of prolonged ras a ...... endent hematopoietic cell line
@en
P2093
H Miyazaki
H Sugahara
I Matsumura
K Hashimoto
K Nakajima
Y Kanakura
P2860
P304
P356
10.1128/MCB.18.7.4282
P407
P577
1998-07-01T00:00:00Z