A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.
about
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factorsActivation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cellsPhosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activityMulti-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cellsA specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cellsIdentification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density.Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determinationA critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.PI3K: from the bench to the clinic and back.Phosphatidylinositol 3-kinase: the oncoprotein.Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatmentThe phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenograftsNuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survivalRegulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.p110δ PI3 kinase pathway: emerging roles in cancer.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell linesEssential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment.Clinical activity of mammalian target of rapamycin inhibitors in solid tumors.Targeting the PI3K pathway for cancer therapy.The Biological Role of PI3K Pathway in Lung Cancer.The Ras mutant D119N is both dominant negative and activated.Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancerEffect of NK4 transduction in bone marrow-derived mesenchymal stem cells on biological characteristics of pancreatic cancer cells.Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines.NK4 gene therapy inhibits HGF/Met-induced growth of human cholangiocarcinoma cells.Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid.Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells.Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt.Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3.Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway.Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells.
P2860
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P2860
A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A function for phosphatidylino ...... -mediated signal transduction.
@ast
A function for phosphatidylino ...... -mediated signal transduction.
@en
type
label
A function for phosphatidylino ...... -mediated signal transduction.
@ast
A function for phosphatidylino ...... -mediated signal transduction.
@en
prefLabel
A function for phosphatidylino ...... -mediated signal transduction.
@ast
A function for phosphatidylino ...... -mediated signal transduction.
@en
P2093
P2860
P356
P1476
A function for phosphatidylino ...... -mediated signal transduction.
@en
P2093
P2860
P304
P356
10.1128/MCB.18.12.7119
P407
P577
1998-12-01T00:00:00Z