Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage
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Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexesPersistent nicotine treatment potentiates amplification of the dihydrofolate reductase gene in rat lung epithelial cells as a consequence of Ras activationMurine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci.Role of autophagy in breast cancer.A mechanism of palindromic gene amplification in Saccharomyces cerevisiae.A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomesInactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability.Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells.ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletionProfiling breast cancer by array CGH.The role of DNA breaks in genomic instability and tumorigenesis.Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancerAutophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesisNucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene.N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.Cell Type-Specific Modulation of Cobalamin Uptake by Bovine Serum.Transient excess of MYC activity can elicit genomic instability and tumorigenesis.A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.The onset and extent of genomic instability in sporadic colorectal tumor progression.De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes.Genome position and gene amplificationCREG1 enhances p16(INK4a) -induced cellular senescence.Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation.Structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification.Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase.Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene.Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations.Shaping of tumor and drug-resistant genomes by instability and selection.Characterization of a hotspot region on chromosome 12 for amplification in ring chromosomes in atypical lipomatous tumors.Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells
P2860
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P2860
Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Gene amplification in a p53-de ...... ons that generate DNA breakage
@ast
Gene amplification in a p53-de ...... ons that generate DNA breakage
@en
type
label
Gene amplification in a p53-de ...... ons that generate DNA breakage
@ast
Gene amplification in a p53-de ...... ons that generate DNA breakage
@en
prefLabel
Gene amplification in a p53-de ...... ons that generate DNA breakage
@ast
Gene amplification in a p53-de ...... ons that generate DNA breakage
@en
P2093
P2860
P356
P1476
Gene amplification in a p53-de ...... ons that generate DNA breakage
@en
P2093
P2860
P304
P356
10.1128/MCB.18.5.3089
P407
P577
1998-05-01T00:00:00Z