Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function
about
The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperoneThe J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.Enumeration of the simian virus 40 early region elements necessary for human cell transformationT antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisA TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigensSimian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.Association of p300 and CBP with simian virus 40 large T antigenInactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen.Multiple, distinct trans-activation functions are encoded by the simian virus 40 large T and small t antigens, only some of which require the 82-residue amino-terminal common domain.Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene productsSimian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.Signal-mediated nuclear transport in simian virus 40-transformed cells is regulated by large tumor antigenHomologous SV40 RNA trans-splicing: a new mechanism for diversification of viral sequences and phenotypes.Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations.Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen.Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen.Inhibition of SV40 large T antigen induced apoptosis by small T antigen.The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene.
P2860
Q24669835-B6BA61DC-85FC-4D0B-A7AB-09096685F09EQ33772346-4D1DF81E-CEC4-440C-BAC0-1E3187C7FB95Q33931645-6D20381D-C71F-435D-ACA6-3FEF78995023Q34117528-E1FA5A51-7983-4FD3-82F1-0D954901749DQ34662543-9ADE40D4-54E2-46FF-AA25-CC998F91F2A2Q35839765-5B7A37F7-5347-4442-AF88-0F4B249C3795Q35859848-F08ADEAC-E249-4EE2-8568-7F66D04EC403Q35897814-F3AAF825-7E83-41B9-BE9E-44C4A4D6EEB0Q36560644-4AB86471-952E-4505-8C46-1F714FC20004Q36571152-27D290EA-ACB5-4F6D-BB08-F8E599F0B565Q36635751-CC96C5C6-9206-4E6E-A491-5B1269850682Q36655649-A6C524E5-3039-4BD5-9F12-BED9127AF10AQ36688604-82817306-DF0A-4004-8919-9FBC53E344F7Q36694070-910B7AED-0F67-4BB6-B5D0-42AA2CF93801Q36798979-431CF37D-AD21-476A-98F7-588A79C9AA1BQ37304717-20D5057D-2BB4-4812-B481-648359A4456EQ37534386-799D0999-5D95-4AD7-B97F-4AB6D4E9F88BQ38290890-27A142F5-4B86-488A-8C2F-BBB386C00EAAQ39874566-F4D5253A-36B1-4343-8525-3966E79E3837Q39878446-A98C2D6E-E9C2-4A68-A891-1C2274D3C921Q39880599-A9155CF8-D692-4D33-B6E1-188092C38D00Q40039575-7E4EC246-883B-410C-B000-B0B048247E05Q40041349-D94F8B42-D351-4CA1-A6AB-3ADBE17421D5Q40044437-0DCA451D-D03F-4A07-A147-7C0255B0FFD8Q40911268-5BE71514-102B-461C-A4C0-A4686316003FQ40922692-3BA3ED59-76BA-4FB4-AFBB-866E56C5DECBQ45742017-4EB624F9-6511-48DA-983B-E79F742AF03D
P2860
Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function
description
1990 nî lūn-bûn
@nan
1990 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Simian virus 40 small tumor an ...... a common transforming function
@ast
Simian virus 40 small tumor an ...... a common transforming function
@en
type
label
Simian virus 40 small tumor an ...... a common transforming function
@ast
Simian virus 40 small tumor an ...... a common transforming function
@en
prefLabel
Simian virus 40 small tumor an ...... a common transforming function
@ast
Simian virus 40 small tumor an ...... a common transforming function
@en
P2093
P2860
P356
P1476
Simian virus 40 small tumor an ...... a common transforming function
@en
P2093
A K Arthur
D A Newsom
D M Livingston
J M Milhaven
J W Ludlow
R Millikan
P2860
P304
P356
10.1073/PNAS.87.19.7448
P407
P577
1990-10-01T00:00:00Z