Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.
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MDM2 is a target of simian virus 40 in cellular transformation and during lytic infectionA simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase.Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations.Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen.Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.
P2860
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P2860
Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Analysis of simian virus 40 sm ...... ransformed by large T antigen.
@en
type
label
Analysis of simian virus 40 sm ...... ransformed by large T antigen.
@en
prefLabel
Analysis of simian virus 40 sm ...... ransformed by large T antigen.
@en
P2860
P1433
P1476
Analysis of simian virus 40 sm ...... transformed by large T antigen
@en
P2093
P2860
P304
P407
P577
1993-03-01T00:00:00Z