The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract

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http://www.wikidata.org/entity/Q33817236
Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15.Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15.Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus.Obesity: Receptors identified for a weight regulator.Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review.Neural Mechanisms of Inflammation-Induced Fever
P2860

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract

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http://www.wikidata.org/entity/Q33817236
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2014 nî lūn-bûn
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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2014 թվականի հունիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
The anorectic actions of the T ...... nucleus of the solitary tract
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The anorectic actions of the T ...... nucleus of the solitary tract
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type
label
The anorectic actions of the T ...... nucleus of the solitary tract
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The anorectic actions of the T ...... nucleus of the solitary tract
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prefLabel
The anorectic actions of the T ...... nucleus of the solitary tract
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The anorectic actions of the T ...... nucleus of the solitary tract
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P1433
P1476
P2093
P2860
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P1476
The anorectic actions of the T ...... nucleus of the solitary tract
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P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0100370
P407
P433
P478
P50
P577
P5875
P698
P932