The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.
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Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control regionA tale of three fingers: the family of mammalian Sp/XKLF transcription factorsEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionGATA1 function, a paradigm for transcription factors in hematopoiesisAdjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.A new element within the T-cell receptor alpha locus required for tissue-specific locus control region activityThe two zinc finger-like domains of GATA-1 have different DNA binding specificitiesGeneration of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of DrosophilaThe LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.Direct analysis of native and chimeric GATA specific DNA binding proteins from Aspergillus nidulansCREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene.Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionFunctional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptorScaffold attachment regions stimulate HSP70.1 expression in mouse preimplantation embryos but not in differentiated tissuesTranscriptional mechanisms underlying hemoglobin synthesis.The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter.Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells.HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF.Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.Sheltering of gamma-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A gamma-globin geneAltered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
P2860
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P2860
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The minimal requirements for a ...... a globin locus control region.
@ast
The minimal requirements for a ...... a globin locus control region.
@en
The minimal requirements for a ...... a globin locus control region.
@nl
type
label
The minimal requirements for a ...... a globin locus control region.
@ast
The minimal requirements for a ...... a globin locus control region.
@en
The minimal requirements for a ...... a globin locus control region.
@nl
prefLabel
The minimal requirements for a ...... a globin locus control region.
@ast
The minimal requirements for a ...... a globin locus control region.
@en
The minimal requirements for a ...... a globin locus control region.
@nl
P2093
P2860
P1433
P1476
The minimal requirements for a ...... ta globin locus control region
@en
P2093
Grosveld F
Philipsen S
P2860
P304
P356
10.1002/J.1460-2075.1993.TB05749.X
P407
P577
1993-03-01T00:00:00Z