Enzymatic H-transfer requires vibration-driven extreme tunneling.
about
Effects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and CatalysisThe importance of ensemble averaging in enzyme kineticsMolecular dynamics and protein function.At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate ReductasePerspective: Defining and quantifying the role of dynamics in enzyme catalysisA new conceptual framework for enzyme catalysisLinking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.Laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase.New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics.An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.Hydrogen tunneling links protein dynamics to enzyme catalysisUpdate 1 of: Tunneling and dynamics in enzymatic hydride transfer.Quantum-dynamical picture of a multistep enzymatic process: reaction catalyzed by phospholipase A(2).Taking Ockham's razor to enzyme dynamics and catalysis.Convex Arrhenius plots and their interpretationBarrier passage and protein dynamics in enzymatically catalyzed reactions.Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactorsPromoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effectsNonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactionsHydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity.The power of integrating kinetic isotope effects into the formalism of the Michaelis-Menten equation.Protein dynamics and enzyme catalysis: the ghost in the machine?Computational replication of the abnormal secondary kinetic isotope effects in a hydride transfer reaction in solution with a motion assisted H-tunneling model.An analysis of reaction pathways for proton tunnelling in methylamine dehydrogenaseEnzymology takes a quantum leap forward.Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase.The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions.Quantum behavior of water protons in protein hydration shellImportance of barrier shape in enzyme-catalyzed reactions. Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent amine dehydrogenases.Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes.Optimizing the Michaelis complex of trimethylamine dehydrogenase: identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base.H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.Efficient estimators for quantum instanton evaluation of the kinetic isotope effects: application to the intramolecular hydrogen transfer in pentadiene.Quantum-instanton evaluation of the kinetic isotope effects.
P2860
Q27681376-562E27BE-98E9-44EE-AF91-899AFD756CAEQ28081632-9EDFC2E2-49A9-4B86-9375-63D3ABC5A3BAQ28248486-5F99C8D7-DD1F-432A-A817-4EF55BE27ED6Q28271287-DA1F96ED-C59C-4F9A-B012-3E9FE30CF003Q28829786-0B753A76-5968-46E0-BEEE-302B8D60760FQ28830226-C2E25684-095D-47E2-BEA8-58B8F3C967A5Q28834243-C1E4F08E-5408-435A-903D-B7A00195FD35Q30047989-9E52EFC8-E9F4-496E-998D-AB2C3A4F8EEBQ30355965-96107C14-A890-4154-9161-B67EB7A61FD2Q33298569-42886379-4F5E-471D-A182-5B7EDC5F3202Q33734600-A699C034-79EE-495E-8115-9354CEEF5BCDQ33758599-077F99CC-5380-4E1C-AF65-69FC6CD98085Q33792054-37DDC4D8-7890-4B6E-924E-FE9B99831DEAQ33794709-D5EF8639-4F58-4766-964D-CDF5FD7D99DBQ34173784-9FAAB414-370C-477F-ACA6-DDD3500FB3B8Q34256033-5C57AF4E-2240-4283-9C3D-571EA1CD3957Q34629994-F59988C2-C913-4E1A-9292-91BAE22262ECQ34707033-C918B411-1CF6-4BB4-B492-2B778F3A3BC8Q34707039-6F172B8F-8590-4D28-B425-5102828723BEQ35081474-4F80DB03-F8CF-4A9F-97C6-72441E854935Q35578715-E0B7CB30-1A9C-4FED-846B-902D2BC2B60DQ35768759-ED4B0FBA-0314-4E8C-AC1F-8BA2BC09D1D3Q35774258-26A5EF21-1322-44C3-9396-AD73D6637F4EQ36549101-9504B66A-1DA1-4306-B500-D8A6BADD8C28Q36973801-9CC8191E-9E95-41C7-8D56-4980B0248421Q37163630-1E051204-B3CC-4B0B-8443-9B7FF61FA64EQ37734232-392991E5-7E37-4702-BD4D-A3805B8B2E1BQ38012191-EA3055D8-B019-4E9C-8968-85A54C31FB24Q38740375-8896ADFE-A048-46F1-AE3A-14B0FAC13B37Q39482505-FB8A8BAA-A605-4A04-9AFD-590A91031C07Q40024905-0D56FD6C-47FE-46C7-BDC0-30D69F7A69F6Q41867851-AC9DFA99-D929-4EA3-BAB4-AA848EFE2714Q41904561-E89F9FC8-579C-41F1-9246-5D4DA0BF0DD9Q41978394-82ACAE9F-0F78-4B67-923A-CF8CD18795E8Q43510350-F4981D37-9756-4C3D-9D29-3E2B4765CA84Q43576565-80E97F64-6F6B-4A73-AD60-B205C552CD7AQ43735170-8C7EAA46-AE40-4246-8119-6E80B51C65B6Q44564228-791B0D54-D4E8-4BA8-8B21-ED7916EDB4D0Q46181178-BC0DC3C1-0537-4D29-BFDC-4407BCDD3473Q46403115-5EF8AB35-D802-44EA-B196-DCF31C8A0E99
P2860
Enzymatic H-transfer requires vibration-driven extreme tunneling.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@ast
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@en
type
label
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@ast
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@en
prefLabel
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@ast
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@en
P2093
P356
P1433
P1476
Enzymatic H-transfer requires vibration-driven extreme tunneling.
@en
P2093
Scrutton NS
Sutcliffe MJ
P304
P356
10.1021/BI982719D
P407
P577
1999-03-01T00:00:00Z