Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
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Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugsMolecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesteraseThe mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMPRolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memoryDevelopment and plasticity of the Drosophila larval neuromuscular junctionDetermination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructsThe human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipramTAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acidHuman PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeMolecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum.Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clonePDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndromePDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationPhosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseIdentification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2Genes expressed in the adult brain of Drosophila and effects of their mutations on behavior: a survey of transmitter- and second messenger-related genes.Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum.Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines.Involvement of type 4 cAMP-phosphodiesterase in the myogenic differentiation of L6 cells.Clinical and molecular genetics of the phosphodiesterases (PDEs).Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterasesRole of PKA in the timing of developmental events in Dictyostelium cells.Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase.Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regionsExpression and regulation of human and rat phosphodiesterase type IV isogenes.Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram.Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.
P2860
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P2860
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
description
1989 nî lūn-bûn
@nan
1989 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@ast
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@en
type
label
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@ast
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@en
prefLabel
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@ast
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@en
P2093
P2860
P356
P1476
Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.10.3604
P407
P577
1989-05-01T00:00:00Z