Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.
about
Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expressionCharacterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D geneIdentification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformDetermination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructsThe human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipramThe unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domainsAssociation with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibitionIdentification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variantsExpression of PDE11A in normal and malignant human tissuesHuman PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeSubcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylationDifferential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administrationAttenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10AMembrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulumMice deficient in phosphodiesterase-4A display anxiogenic-like behaviorThe SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway.Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines.cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase.cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novelPrenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness.The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.
P2860
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P2860
Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@en
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@nl
type
label
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@en
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@nl
prefLabel
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@en
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@nl
P2860
P356
P1476
Alternative splicing of cAMP-s ...... ue-specific isoform, RNPDE4A8.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.2.1065
P407
P577
1996-01-01T00:00:00Z