Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
about
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparumA molecular marker of artemisinin-resistant Plasmodium falciparum malariaSupergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunateDrug resistance genomics of the antimalarial drug artemisininThe interplay between drug resistance and fitness in malaria parasitesMaking the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugsMuddled mechanisms: recent progress towards antimalarial target identificationArtemisinin Action and Resistance in Plasmodium falciparumTargeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistancePlasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia.In vitro adaptation of Plasmodium falciparum reveal variations in cultivability.High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread.Laboratory detection of artemisinin-resistant Plasmodium falciparumArtesunate versus chloroquine infection-treatment-vaccination defines stage-specific immune responses associated with prolonged sterile protection against both pre-erythrocytic and erythrocytic Plasmodium yoelii infection.Flow cytometry-based analysis of artemisinin-resistant Plasmodium falciparum in the ring-stage survival assayDrug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.Model system to define pharmacokinetic requirements for antimalarial drug efficacy.Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytesObserving in real time the evolution of artemisinin resistance in Plasmodium falciparumAn integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparumComparison between Flow Cytometry, Microscopy, and Lactate Dehydrogenase-Based Enzyme-Linked Immunosorbent Assay for Plasmodium falciparum Drug Susceptibility Testing under Field ConditionsHow Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine SensitivityAttenuation of Plasmodium falciparum in vitro drug resistance phenotype following culture adaptation compared to fresh clinical isolates in Cambodia.Fitness of artemisinin-resistant Plasmodium falciparum in vitro.Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasitesHaemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisininsAlternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity.Timing is everything for artemisinin actionIncorporating Stage-Specific Drug Action into Pharmacological Modeling of Antimalarial Drug TreatmentPersistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in UgandaArtemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling.Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studiesCulture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers.Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.Malaria parasite clearance.A mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities.Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
P2860
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P2860
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Altered temporal response of m ...... ial sensitivity to artemisinin
@ast
Altered temporal response of m ...... ial sensitivity to artemisinin
@en
Altered temporal response of m ...... ial sensitivity to artemisinin
@nl
type
label
Altered temporal response of m ...... ial sensitivity to artemisinin
@ast
Altered temporal response of m ...... ial sensitivity to artemisinin
@en
Altered temporal response of m ...... ial sensitivity to artemisinin
@nl
prefLabel
Altered temporal response of m ...... ial sensitivity to artemisinin
@ast
Altered temporal response of m ...... ial sensitivity to artemisinin
@en
Altered temporal response of m ...... ial sensitivity to artemisinin
@nl
P2093
P2860
P50
P356
P1476
Altered temporal response of m ...... ial sensitivity to artemisinin
@en
P2093
Leann Tilley
Maria P Crespo-Ortiz
Nectarios Klonis
P2860
P304
P356
10.1073/PNAS.1217452110
P407
P577
2013-02-19T00:00:00Z