The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
about
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesisMEK5, a new target of the atypical protein kinase C isoforms in mitogenic signalingIdentification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cellsRegulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cellsRegulation of mature T lymphocyte proliferation and differentiation by Par-4A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase.Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologicallyExpression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.The atypical protein kinase Cs. Functional specificity mediated by specific protein adaptersEssential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activationTumour-suppression activity of the proapoptotic regulator Par4.The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.Heat-shock protein 90 alpha (HSP90α) modulates signaling pathways towards tolerance of oxidative stress and enhanced survival of hepatocytes of Mugil cephalus.The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators.Clinical significance of GADD153 expression in stage I non-small cell lung cancer.PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.Role of PAR-4 in ovarian cancer.Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM)Apoptosis and tumor resistance conferred by Par-4Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells.The Par-4/PTEN connection in tumor suppression.PAR-4 as a possible new target for pancreatic cancer therapy.Cancer-selective apoptotic effects of extracellular and intracellular Par-4.Par-4 as a potential target for cancer therapy.pH-induced folding of an apoptotic coiled coil.Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells.Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis.Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis.Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation.Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.
P2860
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P2860
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The downregulation of the pro- ...... survival and tumor progression
@ast
The downregulation of the pro- ...... survival and tumor progression
@en
type
label
The downregulation of the pro- ...... survival and tumor progression
@ast
The downregulation of the pro- ...... survival and tumor progression
@en
prefLabel
The downregulation of the pro- ...... survival and tumor progression
@ast
The downregulation of the pro- ...... survival and tumor progression
@en
P2093
P356
P1433
P1476
The downregulation of the pro- ...... survival and tumor progression
@en
P2093
P304
P356
10.1093/EMBOJ/18.22.6362
P407
P577
1999-11-01T00:00:00Z