Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase
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GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitPhosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationTyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transductionHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorMeasurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisalFunctions of the major tyrosine phosphorylation site of the PDGF receptor beta subunitThe 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase SypA tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorHigh content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligationIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinasePhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeExpression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression systemA novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsAn Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinasesGrb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorAdditive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentPhosphoinositides: tiny lipids with giant impact on cell regulationWortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reactionRole of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementPhosphatidylinositol 3-kinase activity is important for progesterone-induced Xenopus oocyte maturation.Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies.The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes.Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP.Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptorsFRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains.Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactionsData-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activationSystemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132.mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia.The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gelsMembrane-binding/modification model of signaling protein activation and analysis of its control by cell morphologyClass IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase
P2860
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P2860
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase
description
1990 nî lūn-bûn
@nan
1990 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@ast
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@en
type
label
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@ast
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@en
prefLabel
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@ast
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@en
P2860
P1433
P1476
Phosphorylation of the PDGF re ...... phosphatidylinositol 3 kinase
@en
P2093
A Kazlauskas
J A Cooper
P2860
P304
P356
10.1002/J.1460-2075.1990.TB07527.X
P407
P577
1990-10-01T00:00:00Z