Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyA review on hepatocyte nuclear factor-1beta and tumorImproving the efficacy of chemoradiation with targeted agentsEmerging Treatment Paradigms in Radiation OncologyAtaxia-telangiectasia: future prospectsStructure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapiesLB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potentialMolecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage responsePerspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancerChk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell deathDynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cellsDifferential inhibitor sensitivity between human kinases VRK1 and VRK2.A decade of systems biologyInhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabineCombined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.Development of synthetic lethality anticancer therapeutics.Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repairAssessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.Comparative analysis of radiosensitizers for K-RAS mutant rectal cancersTargeting lung cancer through inhibition of checkpoint kinases.Targeting mcl-1 for radiosensitization of pancreatic cancers.Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine.Role of α(5)β(1) Integrin Up-regulation in Radiation-Induced Invasion by Human Pancreatic Cancer CellsIdentification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.DNA repair: from genome maintenance to biomarker and therapeutic target.5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumorsMK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenograftsTherapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancerEvaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype.Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
P2860
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P2860
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@ast
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@en
type
label
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@ast
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@en
prefLabel
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@ast
Mechanism of radiosensitizatio ...... us recombinational DNA repair.
@en
P2093
P2860
P1433
P1476
Mechanism of radiosensitizatio ...... ous recombinational DNA repair
@en
P2093
Christine E Canman
Deborah Morosini
Diane M Simeone
Jonathan Maybaum
Joshua D Parsels
Leslie A Parsels
Linda Hylander-Gans
Maria C Hassan
Mary A Davis
P2860
P304
P356
10.1158/0008-5472.CAN-09-3573
P407
P577
2010-05-25T00:00:00Z