Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
about
Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IIAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionHLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideHLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.Characterization of structural features controlling the receptiveness of empty class II MHC molecules.Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.Binding interactions between peptides and proteins of the class II major histocompatibility complex.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityThe relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.MHC class II complexes sample intermediate states along the peptide exchange pathway.Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysisSingle-molecule motions of MHC class II rely on bound peptides.Thermodynamic analysis of the increased stability of major histocompatibility complex class II molecule I-Ek complexed with an antigenic peptide at an acidic pH.Contribution of a single hydrogen bond between betaHis81 of MHC class II I-E(k) and the bound peptide to the pH-dependent thermal stability.Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.
P2860
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P2860
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@ast
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@en
type
label
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@ast
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@en
prefLabel
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@ast
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@en
P2093
P2860
P356
P1476
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.
@en
P2093
P2860
P304
P356
10.1073/PNAS.151131498
P407
P577
2001-07-24T00:00:00Z