Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini.
about
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanIdentification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)The molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutationDcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathwayTwo related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiaemRNA stability in mammalian cellsmRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activityNonsense-mediated decay of human HEXA mRNA.When a ribosome encounters a premature termination codon.Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon.Unspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cellsIntron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells.When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?Re-capping the message.SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.Uncapped 5' ends of mRNAs targeted by cytoplasmic capping map to the vicinity of downstream CAGE tags.The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzymeIdentification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stabilityCap homeostasis is independent of poly(A) tail length.An efficient strategy to isolate full-length cDNAs based on an mRNA cap retention procedure (CAPture).Determination of mRNA fate by different RNA polymerase II promoters.Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells.Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundanceMammalian nonsense codons can be cis effectors of nuclear mRNA half-life.Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNARecognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position.Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.Analysis of mutations in the yeast mRNA decapping enzyme.Defects in RNA splicing and the consequence of shortened translational reading frames.Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme.Binary specification of nonsense codons by splicing and cytoplasmic translationRNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs.
P2860
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P2860
Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini.
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@ast
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@en
type
label
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@ast
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@en
prefLabel
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@ast
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@en
P2860
P1433
P1476
Human beta-globin mRNAs that h ...... e structure at the 5' termini.
@en
P2093
P2860
P304
P407
P577
1992-09-01T00:00:00Z