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Binary specification of nonsense codons by splicing and cytoplasmic translation

Binary specification of nonsense codons by splicing and cytoplasmic translation

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay Human INT6/eIF3e is required for nonsense-mediated mRNA decay SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells A GFP-based reporter system to monitor nonsense-mediated mRNA decay Splicing of human immunodeficiency virus RNA is position-dependent suggesting sequential removal of introns from the 5' end Ribosome-based quality control of mRNA and nascent peptides Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Mechanism and regulation of the nonsense-mediated decay pathway Mechanisms of deadenylation-dependent decay The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story Mutations of FBN1 and genotype-phenotype correlations in Marfan syndrome and related fibrillinopathies Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives Organizing principles of mammalian nonsense-mediated mRNA decay A novel frameshift mutation in exon 23 of ATP7A (MNK) results in occipital horn syndrome and not in Menkes disease Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay Prediction of protein-destabilizing polymorphisms by manual curation with protein structure.The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.CDS annotation in full-length cDNA sequence.

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Binary specification of nonsense codons by splicing and cytoplasmic translation

http://www.wikidata.org/entity/Q42647080

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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1998年學術文章

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1998年學術文章

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name

Binary specification of nonsense codons by splicing and cytoplasmic translation

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Binary specification of nonsense codons by splicing and cytoplasmic translation

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type

label

Binary specification of nonsense codons by splicing and cytoplasmic translation

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Binary specification of nonsense codons by splicing and cytoplasmic translation

@nl

prefLabel

Binary specification of nonsense codons by splicing and cytoplasmic translation

@en

Binary specification of nonsense codons by splicing and cytoplasmic translation

@nl

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Binary specification of nonsense codons by splicing and cytoplasmic translation

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Deters A

http://www.w3.org/2001/XMLSchema#string

Frede U

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Hagemeier C

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Kulozik AE

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Neu-Yilik G

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Thermann R

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Wehr K

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A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Molecular basis for dominantly inherited inclusion body beta-thalassemia

A versatile in vivo and in vitro eukaryotic expression vector for protein engineering

Frameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.

Nonsense mutations in the human beta-globin gene affect mRNA metabolism.

Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.

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12

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Matthias Hentze

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232797573

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9628884

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1170685

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