The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. - Wikidata - wikimedia - TriplyDB

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.

http://www.wikidata.org/entity/Q33948895

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mTOR Regulation of Lymphoid Cells in Immunity to Pathogens Newtonian cell interactions shape natural killer cell education IL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells Trial Watch-Immunostimulation with cytokines in cancer therapy Harnessing adaptive natural killer cells in cancer immunotherapy The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy Dynamic Metabolism in Immune Response Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.Essential role for autophagy during invariant NKT cell development.Intracellular osteopontin regulates homeostasis and function of natural killer cells.Resident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance.PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness Activation-specific metabolic requirements for NK Cell IFN-γ production.PTEN regulates natural killer cell trafficking in vivo Inflammatory IL-15 is required for optimal memory T cell responses.NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models Development and maturation of natural killer cells FoxO1-mediated autophagy is required for NK cell development and innate immunity.mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism.NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.Homeostasis of IL-15 dependent lymphocyte subsets in the liver.Metabolic Regulation of Natural Killer Cell IFN-γ Production.Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function.Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Interleukin-15 in the treatment of cancer.Evolving perspectives of mTOR complexes in immunity and transplantation.Selection, tuning, and adaptation in mouse NK cell education.Regulation of innate immune cell function by mTOR.Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells.T Cells Going Innate.

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The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.

http://www.wikidata.org/entity/Q33948895

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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The metabolic checkpoint kinas ...... nt and activation of NK cells.

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The metabolic checkpoint kinas ...... nt and activation of NK cells.

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The metabolic checkpoint kinas ...... nt and activation of NK cells.

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Aurore Fenis

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Charlotte Viant

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Jacques Bienvenu

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Jessica Rabilloud

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Julien Cherfils-Vicini

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Katia Mayol

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Sophie Degouve

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P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Posttranscriptional control of T cell effector function by aerobic glycolysis

mTOR is a key modulator of ageing and age-related disease

mTOR signaling in growth control and disease

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

Functions of natural killer cells

Innate lymphoid cells--a proposal for uniform nomenclature

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8

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15

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Antoine Marçais

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