The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
about
mTOR Regulation of Lymphoid Cells in Immunity to PathogensNewtonian cell interactions shape natural killer cell educationIL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer CellsTrial Watch-Immunostimulation with cytokines in cancer therapyHarnessing adaptive natural killer cells in cancer immunotherapyThe shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyDynamic Metabolism in Immune ResponseHepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.Essential role for autophagy during invariant NKT cell development.Intracellular osteopontin regulates homeostasis and function of natural killer cells.Resident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance.PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsivenessActivation-specific metabolic requirements for NK Cell IFN-γ production.PTEN regulates natural killer cell trafficking in vivoInflammatory IL-15 is required for optimal memory T cell responses.NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activityComparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal ModelsDevelopment and maturation of natural killer cellsFoxO1-mediated autophagy is required for NK cell development and innate immunity.mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism.NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activationIL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.Homeostasis of IL-15 dependent lymphocyte subsets in the liver.Metabolic Regulation of Natural Killer Cell IFN-γ Production.Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function.Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Interleukin-15 in the treatment of cancer.Evolving perspectives of mTOR complexes in immunity and transplantation.Selection, tuning, and adaptation in mouse NK cell education.Regulation of innate immune cell function by mTOR.Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells.T Cells Going Innate.
P2860
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P2860
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@ast
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@en
type
label
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@ast
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@en
prefLabel
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@ast
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@en
P2093
P2860
P50
P356
P1433
P1476
The metabolic checkpoint kinas ...... nt and activation of NK cells.
@en
P2093
Armelle Tavares
Aurore Fenis
Charlotte Viant
Eric Gilson
Jacques Bienvenu
Jessica Rabilloud
Julien Cherfils-Vicini
Katia Mayol
Sophie Degouve
P2860
P2888
P304
P356
10.1038/NI.2936
P407
P577
2014-06-29T00:00:00Z
P5875
P6179
1004135147