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Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentMyopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial functionDistinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domainMuscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.The histone fold is a key structural motif of transcription factor TFIID.Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle.Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathyIncreased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coliH2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse musclesLack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Yann-Gaël Gangloff
@ast
Yann-Gaël Gangloff
@en
Yann-Gaël Gangloff
@es
Yann-Gaël Gangloff
@nl
type
label
Yann-Gaël Gangloff
@ast
Yann-Gaël Gangloff
@en
Yann-Gaël Gangloff
@es
Yann-Gaël Gangloff
@nl
prefLabel
Yann-Gaël Gangloff
@ast
Yann-Gaël Gangloff
@en
Yann-Gaël Gangloff
@es
Yann-Gaël Gangloff
@nl
P106
P31
P496
0000-0001-9031-1184