c-Jun mediates axotomy-induced dopamine neuron death in vivo. - Wikidata - wikimedia - TriplyDB

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

http://www.wikidata.org/entity/Q33949411

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Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1 Toxin-Induced Experimental Models of Learning and Memory Impairment JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074 Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling.Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase.Intracellular signalling pathways in dopamine cell death and axonal degeneration.MAPKs: new targets for neurodegeneration.Alzheimer's disease: the pharmacological pathway.JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.Multiple transcription factor families regulate axon growth and regeneration Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3.Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.Nuclear and cytosolic JNK signalling in neurons.Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease.Co-localization of activating transcription factor 3 and phosphorylated c-Jun in axotomized facial motoneurons TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo.The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons.Prostaglandin F2α regulation of mRNA for activating protein 1 transcriptional factors in porcine corpora lutea (CL): lack of induction of JUN and JUND in CL without luteolytic capacity.Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons.PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death.c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death.

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P2860

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

http://www.wikidata.org/entity/Q33949411

description

2001 nî lūn-bûn

@nan

2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@ast

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

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type

label

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@ast

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@en

prefLabel

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@ast

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@en

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Proceedings of the National Academy of Sciences of the United States of America

P1476

c-Jun mediates axotomy-induced dopamine neuron death in vivo.

@en

P2093

D S Park

http://www.w3.org/2001/XMLSchema#string

H Anisman

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P D Smith

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R S Slack

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S J Crocker

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S M Callaghan

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W R Lamba

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P2860

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Signal transduction by the JNK group of MAP kinases

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

The stress-activated protein kinase subfamily of c-Jun kinases

Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype. With a critique of slow transport theory.

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion.

The Effectiveness of the Gene Which Slows the Rate of Wallerian Degeneration in C57BL/Ola Mice Declines With Age.

AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration.

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.

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10.1073/PNAS.231177098

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11687617

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60880

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