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A transcription factor regulatory circuit in differentiated pancreatic cells.

A transcription factor regulatory circuit in differentiated pancreatic cells.

http://www.wikidata.org/entity/Q33951968

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Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations Control of pancreas and liver gene expression by HNF transcription factors FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha Structural Basis of Natural Promoter Recognition by a Unique Nuclear Receptor, HNF4 : DIABETES GENE PRODUCT Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.HNF1alpha is involved in tissue-specific regulation of CFTR gene expression Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Short and long-term impact of lipectomy on expression profile of hepatic anabolic genes in rats: a high fat and high cholesterol diet-induced obese model Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression Type 2 diabetes: hypoinsulinism, hyperinsulinism, or both?Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.Improved conditional expression systems resulting in physiological level of HNF4alpha expression confirm HNF4alpha induced apoptosis in the pancreatic beta-cell line INS-1.ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs.Mitochondrial metabolism and diabetes A map of open chromatin in human pancreatic islets.Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2.Dissecting the transcriptional network of pancreatic islets during development and differentiation.Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3).Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.Prediabetes is associated with HNF-4 α P2 promoter polymorphism rs1884613: a case-control study in Han Chinese population and an updated meta-analysis Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.Differential effects of HNF-1α mutations associated with familial young-onset diabetes on target gene regulation.Genetic approaches to the molecular understanding of type 2 diabetes.Development and diseases of the pancreas.Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus

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P2860

A transcription factor regulatory circuit in differentiated pancreatic cells.

http://www.wikidata.org/entity/Q33951968

description

2001 nî lūn-bûn

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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

A transcription factor regulatory circuit in differentiated pancreatic cells.

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A transcription factor regulatory circuit in differentiated pancreatic cells.

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type

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A transcription factor regulatory circuit in differentiated pancreatic cells.

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A transcription factor regulatory circuit in differentiated pancreatic cells.

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prefLabel

A transcription factor regulatory circuit in differentiated pancreatic cells.

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A transcription factor regulatory circuit in differentiated pancreatic cells.

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Proceedings of the National Academy of Sciences of the United States of America

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A transcription factor regulatory circuit in differentiated pancreatic cells.

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Boj SF

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Ferrer J

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Maestro MA

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Parrizas M

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P2860

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes.

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma

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14481-14486

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10.1073/PNAS.241349398

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25

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