Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
about
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activitiesThe yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machineryRegulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BADYeast Pak1 kinase associates with and activates Snf1Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiaeCdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20.The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityPhosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphologyAndrogen receptor specifically interacts with a novel p21-activated kinase, PAK6The activity of the plexin-A1 receptor is regulated by RacThe four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological propertiesIdentification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2Rho GTPases and their effector proteinsInteractions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding.The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2.Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakBReciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysisHuman immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIXSerine-71 phosphorylation of Rac1 modulates downstream signaling.Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation.Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac.miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM PathwaysMolecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationSeptin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain.Roles of P21-activated kinases and associated proteins in epithelial wound healing.Small-GTPase-associated signaling by the guanine nucleotide exchange factors CpDock180 and CpCdc24, the GTPase effector CpSte20, and the scaffold protein CpBem1 in Claviceps purpurea.Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines.Conformational switch and role of phosphorylation in PAK activationIdentification of p21-activated kinase specificity determinants in budding yeast: a single amino acid substitution imparts Ste20 specificity to Cla4.SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.Dictyostelium PAKc is required for proper chemotaxis.An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex.Substrates enhance autophosphorylation and activation of p21-activated protein kinase gamma-PAK in the absence of activation loop phosphorylation.Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange.A Pak- and Pix-dependent branch of the SDF-1alpha signalling pathway mediates T cell chemotaxis across restrictive barriers.
P2860
Q24312060-0301DEF2-D84A-4880-8C9C-A17202CC8176Q24557447-545AECE7-44AD-4913-9CC6-1B7C9F88BAA5Q24628972-77E6F218-4C8A-4F82-94B5-72278A1A163FQ24679330-38FE9C34-9A1D-4773-8DB5-3977532DBBE4Q27938139-C89A95F9-9E91-45A5-A2EF-56A97EAD581DQ27938669-7B094EA3-101E-4F2E-8D61-0161B4FFF490Q27939001-ECE9ECAA-C382-4A4A-BE54-B39DBBA5889AQ28118693-04E3A8D9-DBC6-4DFF-9627-4CA9222A7D7FQ28199047-A2EBBED8-FAE5-4B41-8CFC-F7313C5831B2Q28208123-C51204B8-4FAB-431E-912F-FF59CD83AD59Q28265990-D1FA9B4F-8393-4435-85EE-F7B6B4AE9DDBQ28281668-1A663782-EBDE-4F0B-BDF9-5519D5E16513Q28586827-28CF9DBB-596A-4442-AA30-EEAC1A5F63A8Q29547740-4EB006C2-500A-4745-BD4D-033BEF9941BCQ30160364-30F99972-A38F-45A2-9F3B-FF9CB6163911Q30165115-0C73FB83-2B28-4238-8AA4-C3451A5C6F86Q30175308-247DC0FC-F4E3-4EA2-AED8-890FE9E1B0A6Q30845395-B073935B-4D88-4939-9C4A-4D891A364CCAQ33538085-3F824C1F-E11F-45F4-9AED-09561A3216ACQ33931747-CC1B4DF4-52F8-4CFE-A594-149C61D2BA46Q34412353-2480EF39-08C6-450A-A701-CEC734BFEABAQ34712138-B5B37846-E528-4AF4-8FA1-29007AAFD4F6Q34926820-88A63174-1F1A-47C3-9C13-1754D910956CQ35676981-873619DE-4FBB-495E-B625-2B7FC340EF0DQ35900778-90E6C365-0B7C-4F13-A454-EF9DE22EACE1Q35952627-14029DDC-633B-4EAE-8E62-C888786D28EAQ36381135-2330D2F3-47E9-404D-9429-03176858DF8AQ36549580-4BDCD168-C69E-46C8-B3C1-4F44A7BF8CDEQ37188103-1B8AEFF3-8B6C-4931-B6B4-2C159393A76FQ37723999-F3A7D079-72F0-47F0-A515-AFB88B38BA95Q37981628-E83962AC-BDB8-43ED-BFF2-F38B667CD5F7Q39460505-F0059BD9-A88F-4B78-BC6F-73EF8949CDDFQ39740330-E44F19E9-8B27-4DD4-AE4E-B8646D4A7300Q40420548-D218E4E4-CC90-4F87-81FC-3A1B47AD123AQ40522054-DC784ACD-886A-4037-94DF-1E4838A8401EQ40859402-40F8DDB7-6CE8-458B-8578-BA16CBBA72D4Q40869886-05C7C74D-BFE4-4112-9A96-C95C4EF6338EQ41700861-D9991C06-8494-41A4-B6D4-95E69DF60F7BQ42134671-6AD986E3-8368-4D6A-AAFC-757BC71B80B6Q42407859-C7A63887-8818-430B-91DF-22CD2783E956
P2860
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@ast
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@en
type
label
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@ast
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@en
prefLabel
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@ast
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@en
P2860
P356
P1476
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
@en
P2860
P304
P356
10.1128/MCB.19.1.602
P407
P577
1999-01-01T00:00:00Z