Conformational switch and role of phosphorylation in PAK activation - Wikidata - wikimedia - TriplyDB

Conformational switch and role of phosphorylation in PAK activation

Conformational switch and role of phosphorylation in PAK activation

http://www.wikidata.org/entity/Q39460505

about

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20.Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1 Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase PAK signalling during the development and progression of cancer Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation Roles of P21-activated kinases and associated proteins in epithelial wound healing.Axon growth and guidance: receptor regulation and signal transduction P21 activated kinases: structure, regulation, and functions.Targeting PAK1.Structure, biochemistry, and biology of PAK kinases.Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.Structural insights into the intertwined dimer of fyn SH2 Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2.B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts Estimation of the available free energy in a LOV2-J alpha photoswitch.A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases.Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin.The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.

P2860

Q24296040-8F548C99-0E5E-4E3E-8A2C-D73FA6C836F9 Q24524132-7CED210B-D46B-48A7-B6C7-F61D656C8B63 Q24530623-8212C936-4B92-4332-8057-A67C506EE63D Q24675149-1F6F1253-7CDE-4979-B92B-D287B73E3F6F Q27642578-B3464766-CBF9-447A-A6CD-3BA8D1783BF7 Q27939001-67ACD0FE-0377-48FB-AA69-E628F09A8DB0 Q28208695-E35931D3-FB3D-4AD9-B455-A0ABAA45451D Q28267434-0E175A07-D389-4B04-AED8-5FF0F024CA7A Q28276857-7972C13F-088D-4C1C-BDBD-A4B919A60485 Q28294146-10B0802D-66D7-460A-8BA1-A1666A45D9D6 Q28307460-64FBCF17-8820-4562-8A00-AE1BACE3686A Q28574106-61EA80CA-63EA-46BD-809A-4E500DE88913 Q30165115-16CA9C21-35F2-478D-B297-043402D40629 Q33936852-945FA763-8741-494D-8D74-C550AAA7DFFA Q34926820-3C9DF4E7-3EA1-4D1E-972E-DA01E726DDF2 Q35952627-9F36A67B-BFA4-4709-8894-C4B411138061 Q36216292-4C613416-252D-4DDE-A85E-A68D36B6193A Q36741576-545F9112-2D39-490D-B54A-38414474A568 Q37188103-90A066AC-AF72-4E78-B9DC-2FADC0B7B6E5 Q37463134-6D4673F8-D451-4A80-868B-58EF091EADBF Q38198494-682BA3E1-D17B-4536-A46C-7037C2CB6382 Q38757029-F127D110-4AD5-4352-BE89-0FC7A94EA90B Q38779105-03F3C815-A40E-48F5-8D20-8760FD7A4DB5 Q39628813-83821520-34E1-458D-8B1D-B3E28DBCEA08 Q39719314-86E2879D-6CD8-450F-BFAE-677D54ACAC56 Q39745856-0C957E1F-7D95-4DC4-B152-3335650A8214 Q39805071-6B83F151-25A2-4FDC-8718-55A76CFF863E Q39959463-C8EA218F-7CB2-4951-9CE8-593C382054F2 Q40040209-AEE06909-1F7D-48CC-926D-01B4F20022B9 Q40106302-46FE124C-88CF-4E67-8815-98B87BBBB7F1 Q40457910-FD0B70F9-172C-4392-9A92-CBE6961CB8F9 Q40572781-86C46F8D-B6FD-484E-987D-30DE9835AF71 Q41136635-0BDABD80-1EE0-477C-8D18-637C5F1795AF Q41513620-1728B6EE-FD25-4BC7-9E63-BE10B6DB8AFC Q41894651-4486D388-BFDE-42E3-9394-6665B9BBDE19 Q42528406-F7BC913B-EC71-4A74-A2B3-1C583D1FFB28 Q44292880-6B3BA284-1CD7-4E7D-A957-1B3293007C08 Q45173722-DCE8A4BA-DBEE-445E-980B-E9FFF66A99B0 Q53060825-9D5DDA0D-5312-435B-A085-EE6DF9D31B80 Q54976847-1B84D149-2B0E-485E-BE96-82D17A3866FC

P2860

Conformational switch and role of phosphorylation in PAK activation

http://www.wikidata.org/entity/Q39460505

description

2001 nî lūn-bûn

@nan

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

2001年论文

@zh

2001年论文

@zh-cn

name

Conformational switch and role of phosphorylation in PAK activation

@en

Conformational switch and role of phosphorylation in PAK activation.

@nl

type

label

Conformational switch and role of phosphorylation in PAK activation

@en

Conformational switch and role of phosphorylation in PAK activation.

@nl

prefLabel

Conformational switch and role of phosphorylation in PAK activation

@en

Conformational switch and role of phosphorylation in PAK activation.

@nl

P1433

Q39460505-FC8D4C78-8A68-4F29-AB28-2515534A7C56

P1476

Q39460505-53BDA46E-3621-49D6-9CE6-60EC525EE090

P2093

Q39460505-15D224CB-D7FB-4745-B4E1-65037F020514

Q39460505-17958D79-EFEF-44B8-943C-1535D1ED76B9

Q39460505-470A5DAE-2F67-45E9-B7BB-D3F630D22B66

Q39460505-566E2ABF-2C60-4D25-BBB2-1662D30A3A9E

Q39460505-60CEF924-B794-41B7-B39B-611FAE9A84A9

Q39460505-6E79B128-7DD8-4968-A366-B259EFDC0F1D

Q39460505-BF50CC72-2EFA-4331-A253-B28D9FEF0CCE

Q39460505-DB3C895B-89B8-423D-AA72-4768EF6E3AF3

P2860

Q39460505-061BB5B3-3BB9-47BD-88A9-F17D7438FDE3

Q39460505-167320F6-7098-44CC-AD76-AB55763EFF7E

Q39460505-20119176-1095-47E2-A707-C94565105357

Q39460505-287D6F64-356A-48C6-BC24-B3708A8C85BE

Q39460505-28C1A094-F959-4E77-9F53-040A11148B7C

Q39460505-2D59DDB5-D6C3-4CBF-96D3-E1A2A76E6C58

Q39460505-3384508A-9524-448C-960B-5D80583900B6

Q39460505-3810D214-3B5F-41E7-8824-A32543244AB9

Q39460505-41272ECF-6287-468A-B6A3-A3D185BCB28B

Q39460505-44911E03-D433-4719-A5DC-DC094965AF9B

P304

Q39460505-E530A1D8-C329-4FBE-91B2-94FC917F45F2

P31

Q39460505-657CE8CD-B7AD-4029-811D-BC2E211F327E

P356

Q39460505-ED4C0AF8-7DB8-4152-AFC0-0BB209720FBA

P407

Q39460505-1F24A2BC-4E50-46AA-A2E5-94FA47E98724

P433

Q39460505-D36EC5F1-6D52-45C2-8AD1-7E44C792E61D

P478

Q39460505-1B9A3B09-7F0B-4CE9-8363-E480DF781A10

P577

Q39460505-D2B15C77-F3CA-4D5C-AF4B-8D82D222FFA8

P5875

Q39460505-FFB4FF47-87D1-4112-8E08-6223B0DB7CAD

P698

Q39460505-97415441-8F96-41AD-A889-6CC81FD4253F

P921

Q39460505-9C654E76-189C-47CD-BA72-CE1A27C23A8C

P932

Q39460505-0E228E1C-F149-4AC0-B8B6-211304F027CB

P356

MCB.21.15.5179-5189.2001

P1433

Molecular and Cellular Biology

P1476

Conformational switch and role of phosphorylation in PAK activation

@en

P2093

Buchwald G

http://www.w3.org/2001/XMLSchema#string

Hostinova E

http://www.w3.org/2001/XMLSchema#string

Kraemer A

http://www.w3.org/2001/XMLSchema#string

Meyer HE

http://www.w3.org/2001/XMLSchema#string

Rudolph MG

http://www.w3.org/2001/XMLSchema#string

Scheffzek K

http://www.w3.org/2001/XMLSchema#string

Sickmann A

http://www.w3.org/2001/XMLSchema#string

Wittinghofer A

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

P304

5179-5189

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.21.15.5179-5189.2001

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P577

2001-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11901868

http://www.w3.org/2001/XMLSchema#string

P698

11438672

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

87242

http://www.w3.org/2001/XMLSchema#string