Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.
about
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytesDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsFunctional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signalingSelected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptorA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationNeurotrophins: roles in neuronal development and functionThe docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathwayCrystal structure of human protein tyrosine phosphatase SHP-1 in the open conformationTyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factorsThrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesInhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptorPTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effectsSHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motilityCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesGas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cellsT-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationDNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphataseMolecular mechanism for a role of SHP2 in epidermal growth factor receptor signalingRole of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.Targeting PTPs with small molecule inhibitors in cancer treatmentThe tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis.Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseExpression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty.A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorPTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneityCritical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.Clinical and molecular aspects of an informative family with neurofibromatosis type 1 and Noonan phenotype.
P2860
Q24291169-259D0289-D3A7-4CA3-812E-F3E9482D04B6Q24300097-0854D89D-5F97-472E-815F-6C7BD17AC955Q24303794-6747E95B-F116-4685-A162-535C54510E3BQ24304242-60CDBC7D-F472-4759-AAE1-D30179F3EA0CQ24307890-C70A40F4-7448-47D0-93BB-CF27DBCECB74Q24318482-55B58BBE-D09C-4C20-BF1B-B4E2D46258C6Q24656166-A1B04A3A-08C3-4D1C-8423-0C3F9C6A49AFQ24799816-2DB60795-1219-4F60-BA77-979743937194Q27667430-6C9384A1-8ED2-4053-8028-E6FCDCD5A039Q28118868-83CDDFFA-DD5F-4235-BED3-03664E65D711Q28142403-D0D975E5-75D1-45F5-910F-00104EDAE31DQ28144746-54DA5032-C237-421B-A712-A2116250A29FQ28201470-346B9764-134F-4160-A13A-E553F09A9073Q28207588-9DC74F88-B49B-48A5-A8A6-9258DC2E8A4EQ28288812-63785AE2-CD0C-46A4-AF3E-E83AC152454EQ28508471-F01C2190-77FD-4EAB-BCC9-E3A6AEBCBCD3Q28513246-9FB23086-5076-4B51-BA2D-25D5B054F607Q28576589-C8E4C618-4882-4F4A-AA22-032F3951B86CQ28590621-31C5E011-E733-43D9-87C2-4FF3BED2D43CQ28590697-DE8495AC-71D2-48CE-9272-DB3219F993F4Q28609932-ECD62497-6955-44C7-8C31-EA66774E9928Q30164884-A15E8380-3AD3-4D94-96E1-50F2C22DE429Q30167815-AA8566B8-FB7B-4DCC-81C4-A654C17780B2Q30168683-51BC205E-6616-49BF-8081-6723C2E03CCFQ33554884-9F52F200-90BD-4E1E-B174-829D05000533Q33605698-19C348D6-5576-40F6-A1BB-47554715AB8CQ33792502-67385B0D-7156-4B78-B451-21E790135584Q33877092-4E888550-F92F-45A6-B33B-D4CAE83605CCQ33929512-751CA323-05BE-4024-A74F-14EF32F238A1Q33940458-0F7A923F-27EC-4BC8-8488-AD2B2DA0A5F0Q33941989-D5C0C8BC-A16D-4F10-A919-693D78F922EEQ33967992-9FD2098A-2028-4E15-909C-85F2471622C2Q34012464-78EA95CD-9A64-497B-979F-9058E185E3C0Q34307028-E9E0F18B-9812-4375-96A3-9CD64795D935Q34496532-55DD191A-40F3-45C4-A198-4171F4CA4F13Q34522913-8E2DC2D9-70E5-4C46-BC98-0B9336CCDE0FQ34649044-275C12E9-0480-43CD-8DC4-4F2286712B8CQ35195305-BFA8D690-8560-4910-8D17-369D63716067Q35615838-05A96D63-0ED7-4393-A392-C51304026448Q35626464-C658057C-A3CA-4327-8AEC-0D013D4FC18B
P2860
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@ast
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@en
type
label
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@ast
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@en
prefLabel
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@ast
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@en
P2093
P2860
P1476
Molecular mechanism for the Sh ...... r stimulation of Erk activity.
@en
P2093
P2860
P304
P356
10.1128/MCB.20.5.1526-1536.2000
P407
P577
2000-03-01T00:00:00Z