Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.
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Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulationMolecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontinInsulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function.Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?PTEN deficiency: a role in mammary carcinogenesis.Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoc-Src-null mice exhibit defects in normal mammary gland development and ERalpha signalingRegulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiationProliferation and apoptosis in mammary epithelium during the rat oestrous cyclePhysiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumorsAkt1 governs breast cancer progression in vivo.Gene regulatory networks in lactation: identification of global principles using bioinformatics.Mechanical strain induces involution-associated events in mammary epithelial cells.Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models.Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells.miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1.Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic miceNovel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cellsTwo distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.Met-related receptor tyrosine kinase Ron in tumor growth and metastasis.Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progressionInduction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Akt/protein kinase B promotes organ growth in transgenic mice.Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasisReactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cellsParallel analysis of transcript and translation profiles: identification of metastasis-related signal pathways differentially regulated by drug and genetic modifications.Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors.PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium.Protein kinases in mammary gland development and cancer.Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscleAkt is required for Stat5 activation and mammary differentiation.The role of prolactin in mammary carcinoma.The prognostic value of phosphorylated AKT expression in non-small cell lung cancer: a meta-analysis.Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesisGlucose metabolism measured by [¹⁸F]fluorodeoxyglucose positron emission tomography is independent of PTEN/AKT status in human colon carcinoma cells.MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.
P2860
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P2860
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Activation of Akt (protein kin ...... equired for tumor progression.
@ast
Activation of Akt (protein kin ...... equired for tumor progression.
@en
type
label
Activation of Akt (protein kin ...... equired for tumor progression.
@ast
Activation of Akt (protein kin ...... equired for tumor progression.
@en
prefLabel
Activation of Akt (protein kin ...... equired for tumor progression.
@ast
Activation of Akt (protein kin ...... equired for tumor progression.
@en
P2093
P2860
P1476
Activation of Akt (protein kin ...... equired for tumor progression.
@en
P2093
J Hutchinson
J R Woodgett
R D Cardiff
W J Muller
P2860
P304
P356
10.1128/MCB.21.6.2203-2212.2001
P407
P577
2001-03-01T00:00:00Z