Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens. - Wikidata - wikimedia - TriplyDB

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

http://www.wikidata.org/entity/Q33988920

about

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.New and emerging technologies for genetic toxicity testing.Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in rats In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.A regenerative erythropoietic response does not increase the frequency of Pig-a mutant reticulocytes and erythrocytes in Sprague-Dawley rats.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea.In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse.

P2860

Q33856344-8767438B-6200-4671-B0B8-82A0EAEB5D74 Q34248313-E0F1F91B-E9EF-42D0-BD4E-A2CC1BA70BE1 Q35400183-C61445B3-36C7-4B05-8F35-CE8960BC33D6 Q35528022-6A02696F-1FE4-4F51-A78E-7EDD4141A3E7 Q35578148-AF4141FC-E722-4412-A5C5-5FD03F77ABE9 Q35578151-CE861562-EA31-4C2E-A1C7-D4330A84E132 Q35673460-70BAF606-30B0-4828-95C5-401E6B739F6B Q35862975-870C8E22-7FC3-4A6F-81B3-DA6110ECBBDB Q36400845-2A4706DA-6B71-4A63-85E3-877022726AEF Q37782591-773D7A51-D14A-4950-89B2-780E05B87C3A Q37942808-FE88FE2A-200A-461C-A013-2BF0B3402244 Q38326587-AD6E0D12-5982-4B6B-A406-46CC110876F2 Q38612050-D19D4A5E-1A00-4337-BBB1-8A14FCFB77DD Q38676314-8BC7CC8F-359E-438B-8489-DF208E0C2A0B Q38938466-41C38B77-02FB-4E7A-80A7-4F01E4D19076 Q38960044-D490816B-8E12-4530-9C09-A68D7B75C0F2 Q39290632-D0B8C588-B794-49A1-A857-3A626E863399 Q41144342-F787181E-1B99-4B6D-8208-1A91F1CD6288 Q41437756-7781D47E-BA18-4FB7-8C3B-36CCB3B36B23 Q42026868-BAE97F33-CAD5-40CE-ADD3-DDCC0C627CD5 Q42517543-5694494D-846B-4D03-9A3F-E0A6EA7A9125 Q42708998-3D5CB2D7-EBF7-4B58-9CB9-1FC52A78E7A6 Q42717300-0603FA37-B5DA-4F8D-B14A-AE53D322C16B Q42722832-5E20860E-1CD0-4E97-99B4-E2ECFFD7FC78 Q42728023-1A288C73-637A-4C98-A866-06EDBD79AB5D Q43486855-FEB7E414-89EB-4FB8-8BF7-766F251CD2D2 Q43576147-737436C8-AF84-45A3-AEAB-04B9A6009F71 Q43865749-C8B5EB88-F0CE-43FF-B073-1C4DDBD23C63 Q44505804-84F923C4-46F6-4071-9AB3-47E72E4A515C Q46747455-D28683E8-A4E1-47B9-91C2-DFDB01C8AB4E Q50460175-77522F36-9786-4F8F-9CF7-EB1BCFE4A51A Q50477771-E66671BA-F5F4-4E06-AC8C-0F05961ADCDA Q50520691-EABF7116-0A42-4C98-A60E-FCFCB375CEC7 Q52761001-9B8FC41A-2067-4806-BEBE-DEF2695A672B Q53085590-77AB7874-D86A-4838-80F1-44180A56C945 Q53142660-F8F3BD4E-C9BE-4B1A-81A2-862180ECAC78 Q54549982-FB994E11-801B-4CFA-8E97-D6D25D5BD522

P2860

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

http://www.wikidata.org/entity/Q33988920

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

name

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@ast

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@en

type

label

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@ast

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@en

prefLabel

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@ast

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@en

P1433

Q33988920-E1E4C89F-D549-4BDD-80FE-857C7BA07010

P1476

Q33988920-EBF40F72-E4C3-47A3-B363-E885BB7CD10F

P2093

Q33988920-12A44E46-A779-4874-A876-4B3589C5064B

Q33988920-1DA88244-1E2E-45C6-A2B9-AE2B19506527

Q33988920-3061A9A5-68C3-4C2B-A9CF-476251F4FB51

Q33988920-3B5C5D7C-828A-404E-B7AC-B804C75BB382

Q33988920-6BEF2B66-425A-48E5-8CF5-789EA4645E5C

Q33988920-6DDA166C-E3B3-4A5A-9A47-D6D03621DCC5

Q33988920-71B66F0D-EBF6-40DA-99FC-9D413E72B9A8

Q33988920-997D8D83-3417-4AE6-9E4C-48B353437A12

Q33988920-D1CC9547-23A5-47FF-8F07-EDDAF66B6903

Q33988920-DF7B6796-E9D9-40C6-A048-4414F47A1ABA

P2860

Q33988920-1B84412D-5D60-482E-9DCD-478E25F7D158

Q33988920-1F056A3D-900B-4839-8B80-2CF657DB93B5

Q33988920-20B58677-4C4F-485F-95D5-32B129FA9013

Q33988920-22F6626C-E5E0-43AA-A9FE-C302252FD8E3

Q33988920-32D755F1-DCC8-4946-851E-D42C00BB7C87

Q33988920-3A56B8DB-2654-470B-88EF-5BDA35A76E3C

Q33988920-5497265A-59D2-4B0E-BE83-154036F33EA1

Q33988920-5F150181-BDE0-480D-B106-40CFC57987AF

Q33988920-661FAC80-DE77-461E-ABA3-4DEF5AA7349A

Q33988920-7505B32B-3A49-4029-A9E7-C12790AA79E2

P304

Q33988920-66D89A6F-8114-48D6-A4F1-53BF65842AFE

P31

Q33988920-C7F19DED-2739-49B3-B8D9-327FE5C9CDAA

P356

Q33988920-829D6C3F-3F91-4A88-BA8A-B18CA018A49C

P433

Q33988920-5A33C4C7-8211-4DE8-8198-660C692D8823

P478

Q33988920-AE7825F4-FA3D-43A5-AA50-5AB64F8F2BD4

P577

Q33988920-5CA85B12-9BC3-4679-85EB-4246082A5E27

P5875

Q33988920-7260A3FF-CF40-4E88-A502-3D2D9BEE1914

P698

Q33988920-CC49D253-F3E4-4AE9-830D-A92DAA5650BD

P932

Q33988920-6C527CE3-6405-4D72-928C-B7A1E639ACB1

P356

P1433

Toxicological Sciences

P1476

Pig-a mutation: kinetics in ra ...... to five prototypical mutagens.

@en

P2093

Dean Franklin

http://www.w3.org/2001/XMLSchema#string

Dorothea K Torous

http://www.w3.org/2001/XMLSchema#string

James Palis

http://www.w3.org/2001/XMLSchema#string

James T Macgregor

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Bemis

http://www.w3.org/2001/XMLSchema#string

Ollivier Hyrien

http://www.w3.org/2001/XMLSchema#string

Pamela Weller

http://www.w3.org/2001/XMLSchema#string

Sarojini Raja

http://www.w3.org/2001/XMLSchema#string

Souk Phonethepswath

http://www.w3.org/2001/XMLSchema#string

Stephen D Dertinger

http://www.w3.org/2001/XMLSchema#string

P2860

Stem cells, cancer, and cancer stem cells

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications

Cancer stem cells: models and concepts

Paroxysmal nocturnal hemoglobinuria: An acquired genetic disease.

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals

Leukemic stem cells: where do they come from?

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.

Stem cell concepts renew cancer research.

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents.

P304

59-70

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/TOXSCI/KFP289

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

114

http://www.w3.org/2001/XMLSchema#string

P577

2009-12-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40452926

http://www.w3.org/2001/XMLSchema#string

P698

19965957

http://www.w3.org/2001/XMLSchema#string

P932

2902916

http://www.w3.org/2001/XMLSchema#string