Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
about
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient miceIntegration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneEfficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats.Genotoxicity testing: moving beyond qualitative "screen and bin" approach towards characterization of dose-response and thresholds.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice.Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.Report on stage III Pig-a mutation assays using benzo[a]pyrene.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment.Safety evaluation of zinc threoninate chelate.Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene.Establishing a novel Pig-a gene mutation assay in L5178YTk(+/-) mouse lymphoma cells.Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.CD48-deficient T-lymphocytes from DMBA-treated rats have de novo mutations in the endogenous Pig-a gene.The in vivo Pig-a gene mutation assay is useful for evaluating the genotoxicity of ionizing radiation in mice.Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea.In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
P2860
Q33854259-3F59BE0D-6A0D-4E85-8FBC-CBCDDFD4FA7EQ33856344-3A37D58F-3F02-4A5F-9903-07CB5AC03747Q33988920-82B5DEF6-CF85-4E2D-92CF-487B90945AD7Q34334564-BE684C69-E3E8-445D-9592-40F24D3AA1EEQ35673460-AC040B78-31E5-4858-B4C6-0BE78EF48145Q35862975-1769545E-90B4-4E19-AB09-238BDD433266Q36400845-01B0CC45-524E-43BB-B741-E60E8FEF6C50Q37346788-E954D201-7F7F-4AC8-9C81-5AEB3996BAC0Q37566252-C90C23F8-0F79-4979-A38C-0E39B935B14BQ37784158-431C962A-D29D-4FCB-B28E-8201018D2DCBQ38676314-F1706CC2-8791-431E-9E58-5512B1A3A39CQ38938466-1DDDCC81-CEA9-40A9-8126-8CE877903747Q39290632-B678D6D1-A343-4E46-B4AD-1DA2D3BFF4B4Q39591347-4B8A99D3-5A3F-4144-9964-F5D70A330231Q39990800-9820B3E1-42F3-4536-BE55-D6DDA88D6CA0Q41144342-F68675BE-C652-4CE0-9518-27FEF4F7DDC1Q42026868-FFB77CB2-6936-43AA-A1D3-25C84614A080Q42708998-1D7321FD-5FF3-4B1C-87FB-2816FF8EFA66Q42717300-CB8D4ECB-119A-4BCD-B445-376E71CBE7C0Q42725437-5EBD45F7-A963-4032-912F-7F5D3C1FB460Q42728023-07011154-149C-4764-A785-39F10194DBBAQ42881529-57865702-0344-4B9E-B8CB-3937C2A0C4EFQ42968962-24F8C807-6776-403F-9634-8AF2B9FC4BAAQ43576147-BB8481AE-EEE5-432B-AEAA-19CF01BAF8B4Q44505804-2F371153-D08F-4595-87D8-A032AE0B8BCEQ46098496-E87A137E-D9B6-4021-8700-792F0EE596A3Q46426275-F09551DB-82C2-4FE4-AE1A-02C0B89DFD15Q47410180-E24D958D-BC50-40F1-82AB-1EF0B8FC288BQ47446227-9F8156D4-0D73-483C-AEAC-B292DD47EECCQ48711056-FB340AC8-CB5B-432A-BDD8-5567CB0C753FQ50443846-CD337272-DD17-417C-AFF1-5B886123ABB6Q50504892-1DF0A742-301D-4746-BF21-3587E332D6B2Q50520691-38DDF0C1-4BCB-4695-8B89-0B4F387F3EDCQ52761001-253205AF-0891-41D6-BDB6-E223757025E0Q53085590-E22F7227-2791-4B65-83CA-5329AE70A5A7Q53142660-AC586D2E-AA2F-4282-BF32-C084E092ABD3
P2860
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 26 August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@en
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@nl
type
label
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@en
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@nl
prefLabel
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@en
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@nl
P2093
P2860
P1433
P1476
Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.
@en
P2093
Jeffrey C Bemis
Souk Phonethepswath
Stephen D Dertinger
Steven M Bryce
P2860
P304
P356
10.1016/J.MRGENTOX.2008.08.011
P407
P577
2008-08-26T00:00:00Z