Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
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Paroxysmal nocturnal hemoglobinuria from bench to bedsideHow I treat paroxysmal nocturnal hemoglobinuriaPIG-A mutations in paroxysmal nocturnal hemoglobinuria and in normal hematopoiesisThe rate of spontaneous mutations in human myeloid cellsStochastic dynamics and the evolution of mutations in stem cellsCompartmental architecture and dynamics of hematopoiesis.Hypomegakaryocytic thrombocytopenia (HMT): an immune-mediated bone marrow failure characterized by an increased number of PNH-phenotype cells and high plasma thrombopoietin levels.Paroxysmal nocturnal hemoglobinuria with copy number-neutral 6pLOH in GPI (+) but not in GPI (-) granulocytesIntegration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.Implications of recent insights into the pathophysiology of paroxysmal nocturnal haemoglobinuria.Paroxysmal nocturnal haemoglobinuria: nature's gene therapy?Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria.Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.PIG-A mutations in normal hematopoiesisParoxysmal nocturnal hemoglobinuriaCytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria.The frequency of granulocytes with spontaneous somatic mutations: a wide distribution in a normal human populationApplication of the molecular analysis of the T-cell receptor repertoire in the study of immune-mediated hematologic diseases.Paroxysmal nocturnal hemoglobinuria clones in children with acquired aplastic anemia: a multicentre study.Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape.Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.A new aspect of the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria.The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH).The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cellsLeukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia.Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuriaFavorable outcome of patients who have 13q deletion: a suggestion for revision of the WHO 'MDS-U' designationRecent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria.Neutral evolution in paroxysmal nocturnal hemoglobinuriaErythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH.Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuriaSensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma.The pathophysiology of paroxysmal nocturnal hemoglobinuria and treatment with eculizumab.Spontaneously arising red cells with a McLeod-like phenotype in normal donors.
P2860
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P2860
Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Clonal populations of hematopo ...... present in normal individuals
@ast
Clonal populations of hematopo ...... present in normal individuals
@en
type
label
Clonal populations of hematopo ...... present in normal individuals
@ast
Clonal populations of hematopo ...... present in normal individuals
@en
prefLabel
Clonal populations of hematopo ...... present in normal individuals
@ast
Clonal populations of hematopo ...... present in normal individuals
@en
P2093
P2860
P356
P1476
Clonal populations of hematopo ...... present in normal individuals
@en
P2093
D J Araten
K Pakdeesuwan
L Luzzatto
P2860
P304
P356
10.1073/PNAS.96.9.5209
P407
P577
1999-04-01T00:00:00Z