Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
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Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapySingle cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneGenotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.Cigarette smoke induced genotoxicity and respiratory tract pathology: evidence to support reduced exposure time and animal numbers in tobacco product testing.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Dietary folic acid protects against genotoxicity in the red blood cells of mice.In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents.Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen.Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.An integrative test strategy for cancer hazard identification.No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.
P2860
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P2860
Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Efficient monitoring of in viv ...... om 11 new reference compounds.
@ast
Efficient monitoring of in viv ...... om 11 new reference compounds.
@en
type
label
Efficient monitoring of in viv ...... om 11 new reference compounds.
@ast
Efficient monitoring of in viv ...... om 11 new reference compounds.
@en
prefLabel
Efficient monitoring of in viv ...... om 11 new reference compounds.
@ast
Efficient monitoring of in viv ...... om 11 new reference compounds.
@en
P2093
P2860
P356
P1476
Efficient monitoring of in viv ...... om 11 new reference compounds.
@en
P2093
Dorothea K Torous
James T Macgregor
Jared Mereness
Jeffrey C Bemis
Pamela Weller
Souk Phonethepswath
Stephen D Dertinger
Steven M Bryce
Svetlana L Avlasevich
P2860
P304
P356
10.1093/TOXSCI/KFS258
P577
2012-08-24T00:00:00Z