On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
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Recent Advances Toward the Discovery of Drug-Like Peptides De novoGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsRational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 InhibitorsThe cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motifSynthesis of Hybrid Cyclopeptides through Enzymatic MacrocyclizationLarge ring-forming alkylations provide facile access to composite macrocyclesDirect Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library.Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally AbsorbedPlucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsTechnologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides.Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides.Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistImpact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.How proteins bind macrocycles.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Synthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues.Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming.cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? .Anthranilic acid-containing cyclic tetrapeptides: at the crossroads of conformational rigidity and synthetic accessibilityTesting physical models of passive membrane permeation.Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.Effect of ester to amide or N-methylamide substitution on bacterial membrane depolarization and antibacterial activity of novel cyclic lipopeptidesBeyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Therapeutic potential of conopeptides.N-methylation of peptides and proteins: an important element for modulating biological functions.Delivery of therapeutic peptides and proteins to the CNS.Strategic approaches to optimizing peptide ADME propertiesNew Modalities for Challenging Targets in Drug Discovery.Getting across the cell membrane: an overview for small molecules, peptides, and proteins.Addressing the right targets in oncology: challenges and alternative approaches.Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.Cell-Permeable Peptides Containing Cycloalanine Residues.Modifying peptides to enhance permeability.Review backbone N-modified peptides: How to meet the challenge of secondary amine acylation.Rational, computer-enabled peptide drug design: principles, methods, applications and future directions.
P2860
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P2860
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@ast
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@en
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@nl
type
label
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@ast
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@en
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@nl
prefLabel
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@ast
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@en
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@nl
P2093
P2860
P356
P1476
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.
@en
P2093
Alan M Mathiowetz
Amit S Kalgutkar
Arthur C Rand
Cayla M McEwen
Chad M Renzelman
David A Price
Jonathan N Bauman
Matthew P Jacobson
R Scott Lokey
Roger G Linington
P2860
P2888
P304
P356
10.1038/NCHEMBIO.664
P577
2011-09-25T00:00:00Z
P5875
P6179
1011760594