Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.
about
Stable alteration of pre-mRNA splicing patterns by modified U7 small nuclear RNAsCurrent and future alternative therapies for beta-thalassemia majorBeta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyThe potential of gene therapy approaches for the treatment of hemoglobinopathies: achievements and challengesA negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Transient in vivo beta-globin production after lentiviral gene transfer to hematopoietic stem cells in the nonhuman primateGene therapy for the hemoglobin disorders: past, present, and future.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementThe beta-globin locus control region versus gene therapy vectors: a struggle for expression.Gene therapy for hemoglobinopathies: the state of the field and the future.Advances in experimental treatment of beta-thalassaemia.Silencing of gene expression: implications for design of retrovirus vectors.Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.Chicken HS4 insulators have minimal barrier function among progeny of human hematopoietic cells transduced with an HIV1-based lentiviral vector.Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity.Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypesLong-term expression of gamma-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human gamma-globin gene fused to the ankyrin-1 promoter.Gene therapy for β-thalassaemia: the continuing challenge.Physiological and tissue-specific vectors for treatment of inherited diseases.Gene therapy in thalassemia and hemoglobinopathies.Genetic strategies for the treatment of sickle cell anaemia.Recent advances in gene therapy for thalassemia.Development of gene therapy for thalassemia.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.Emerging cellular and gene therapies for congenital anemias.Gene Therapy for β-Hemoglobinopathies.Comparative analysis of FV vectors with human α- or β-globin gene regulatory elements for the correction of β-thalassemia.The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells.Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression.Efficient c-kit receptor-targeted gene transfer to primary human CD34-selected hematopoietic stem cells.Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Analysis of enhancer function of the HS-40 core sequence of the human alpha-globin cluster.The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia.High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.Retrovirus molecular conjugates. A novel, high transduction efficiency, potentially safety-improved, gene transfer system.
P2860
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P2860
Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Generation of a high-titer ret ...... of the human beta-globin gene.
@ast
Generation of a high-titer ret ...... of the human beta-globin gene.
@en
Generation of a high-titer ret ...... of the human beta-globin gene.
@nl
type
label
Generation of a high-titer ret ...... of the human beta-globin gene.
@ast
Generation of a high-titer ret ...... of the human beta-globin gene.
@en
Generation of a high-titer ret ...... of the human beta-globin gene.
@nl
prefLabel
Generation of a high-titer ret ...... of the human beta-globin gene.
@ast
Generation of a high-titer ret ...... of the human beta-globin gene.
@en
Generation of a high-titer ret ...... of the human beta-globin gene.
@nl
P2093
P2860
P356
P1476
Generation of a high-titer ret ...... of the human beta-globin gene.
@en
P2093
F Grosveld
M Antoniou
M Sadelain
R C Mulligan
P2860
P304
P356
10.1073/PNAS.92.15.6728
P407
P577
1995-07-01T00:00:00Z