A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 - Wikidata - wikimedia - TriplyDB

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

http://www.wikidata.org/entity/Q34064832

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Regulation of myeloid leukaemia by the cell-fate determinant Musashi Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors Animal models of leukemia: any closer to the real thing?The role of NUP98 gene fusions in hematologic malignancy NUP98 dysregulation in myeloid leukemogenesis ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance Imaging hematopoietic precursor division in real time.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation.JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review Mouse models of myelodysplastic syndromes.NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia.Chronic myeloid leukemia: mechanisms of blastic transformation Stem cells, aging, and cancer: inevitabilities and outcomes.Evidence of B cell immune responses to acute lymphoblastic leukemia in murine allogeneic hematopoietic stem cell transplantation recipients treated with donor lymphocyte infusion and/or vaccination.Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation.Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.The biology of chronic myelogenous leukemia:mouse models and cell adhesion.Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.Right on target: eradicating leukemic stem cells.Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights Leukemia stem cells: the root of chronic myeloid leukemia Mechanisms controlling pathogenesis and survival of leukemic stem cells.Leukemia stem cells in a genetically defined murine model of blast-crisis CML.Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia Animal models of acute myelogenous leukaemia - development, application and future perspectives.A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.β-Arrestin2 mediates the initiation and progression of myeloid leukemia.Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease.CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1 Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

http://www.wikidata.org/entity/Q34064832

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

@en

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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type

label

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

@en

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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prefLabel

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

@ast

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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Proceedings of the National Academy of Sciences of the United States of America

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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Ajeeta B Dash

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D Gary Gilliland

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David Housman

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Ema Anastasiadou

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Jeffery L Kutok

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Julian Borrow

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Kathleen Lindahl

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Michael H Tomasson

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Richard A Van Etten

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Shaoguang Li

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P2860

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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7622-7627

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scholarly article

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10.1073/PNAS.102583199

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11

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99

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Brian J. Druker

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2002-05-01T00:00:00Z

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11340841

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12032333

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124303

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