Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. - Wikidata - wikimedia - TriplyDB

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

http://www.wikidata.org/entity/Q34067223

about

Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor Retroviral intasome assembly and inhibition of DNA strand transfer Multifunctional facets of retrovirus integrase Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage Retroviral Integrase: Then and Now A historical sketch of the discovery and development of HIV-1 integrase inhibitors Drug-class specific impact of antivirals on the reproductive capacity of HIV Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor Human immunodeficiency virus reverse transcriptase and protease sequence database Investigation of the structural requirement for inhibiting HIV integrase: QSAR study.In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.A novel small molecular weight compound with a carbazole structure that demonstrates potent human immunodeficiency virus type-1 integrase inhibitory activity.Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor HIV-1 IN inhibitors: 2010 update and perspectives HIV-1 reverse transcriptase and antiviral drug resistance. Part 1.A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.Resistance to integrase inhibitors.Structure-based modeling of the functional HIV-1 intasome and its inhibition Human immunodeficiency virus type 1 (HIV-1) integrase: resistance to diketo acid integrase inhibitors impairs HIV-1 replication and integration and confers cross-resistance to L-chicoric acid.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Bulged DNA substrates for identifying poxvirus resolvase inhibitors Metal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitro Retroviral integrase proteins and HIV-1 DNA integration Retroviral Integrase Structure and DNA Recombination Mechanism Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.Binding modes of diketo-acid inhibitors of HIV-1 integrase: a comparative molecular dynamics simulation study.Allosteric inhibitor development targeting HIV-1 integrase.HIV-1 integrase strand transfer inhibitors stabilize an integrase-single blunt-ended DNA complex FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

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P2860

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

http://www.wikidata.org/entity/Q34067223

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2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年學術文章

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Proceedings of the National Academy of Sciences of the United States of America

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Diketo acid inhibitor mechanis ...... of phosphotransferase enzymes.

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Abigail Wolfe

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Amy S Espeseth

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Binghua Hu

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Daria J Hazuda

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Jay A Grobler

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Jeffrey Melamed

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Joseph Vacca

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Kara Stillmock

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Marc Witmer

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P2860

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations

Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase

DNA polymerases: structural diversity and common mechanisms

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10.1073/PNAS.092056199

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10

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11997448

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