Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest - Wikidata - wikimedia - TriplyDB

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

http://www.wikidata.org/entity/Q35544616

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ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair Unwinding and rewinding: double faces of helicase?Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability The RecQ DNA helicases in DNA repair Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex RecQ helicases in DNA double strand break repair and telomere maintenance.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.Preventing replication fork collapse to maintain genome integrity Hpz1 modulates the G1-S transition in fission yeast Mutation of the murine Bloom's syndrome gene produces global genome destabilization ATR: an essential regulator of genome integrity BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.Unwinding protein complexes in ALTernative telomere maintenance.SUMO modification regulates BLM and RAD51 interaction at damaged replication forks.Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.RecQ helicases: guardian angels of the DNA replication fork.DNA replication arrest leads to enhanced homologous recombination and cell death in meristems of rice OsRecQl4 mutants.ATR contributes to telomere maintenance in human cells The HRDC domain of BLM is required for the dissolution of double Holliday junctions Deficiency of Bloom syndrome helicase activity is radiomimetic Regulation of BLM Nucleolar Localization Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair Time to bloom.Genetic interactions between BLM and DNA ligase IV in human cells.Werner protein protects nonproliferating cells from oxidative DNA damage A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

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Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

http://www.wikidata.org/entity/Q35544616

description

2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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type

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

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MCB.24.3.1279-1291.2004

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Molecular and Cellular Biology

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Phosphorylation of the Bloom's ...... n recovery from S-phase arrest

@en

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Alwyn Dart

http://www.w3.org/2001/XMLSchema#string

Ian D Hickson

http://www.w3.org/2001/XMLSchema#string

Nicholas D Lakin

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Phillip S North

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Sally L Davies

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P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

Functional and physical interaction between WRN helicase and human replication protein A

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

Regulation and localization of the Bloom syndrome protein in response to DNA damage

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The Bloom's syndrome gene product is homologous to RecQ helicases

Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)

PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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1279-1291

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10.1128/MCB.24.3.1279-1291.2004

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14729972

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phosphorylation

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321429

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