ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
about
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linkingMolecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of functionConjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSNeuroinflammation in motor neuron diseasePathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersThe involvement of microRNAs in neurodegenerative diseasesConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe function of RNA-binding proteins at the synapse: implications for neurodegenerationTherapeutic and diagnostic challenges for frontotemporal dementiaDoes a loss of TDP-43 function cause neurodegeneration?Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegansHyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationFUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosisThe crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acidsTDP-43 aggregation in neurodegeneration: are stress granules the key?TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control terminationElucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approachesMutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosisIdentification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexesCorrelating disease-related mutations to their effect on protein stability: a large-scale analysis of the human proteome.Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed.Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 speciesPartial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrityThe RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.Sphingosine kinase 1 isoform-specific interactions in breast cancerQuantitative analysis of cryptic splicing associated with TDP-43 depletion.RNA metabolism in neurodegenerative disease.TDP-43 regulates its mRNA levels through a negative feedback loop.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismTDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organizationMolecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSAutophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination
P2860
Q24300438-00139478-9F6A-4DD9-8220-F3A2B00CF312Q24314515-8EBEEF57-2FA1-45FC-96C4-A3E65A743834Q24634807-EF092D00-96DD-4F68-B492-D05A71191546Q26776339-D64903E5-CB53-4546-85E2-D29219E41CECQ26828357-4C7E02F9-5483-4D24-930B-1D24BD0CB484Q26858788-F972A6F2-D4CB-486B-BD97-9B01CBD1B7FDQ26863439-B53F6CC9-DD02-4DD1-989F-22771E49016CQ26991684-27E964ED-6BB7-4F81-B9D8-FB071C2DBB81Q26998919-72269F69-A459-4237-922A-6556A7BEE8C9Q27026848-3435D108-1A4C-4247-80EB-ADEC4B0F6988Q27309039-5B88E068-0FBA-4EAA-BDEB-805AEFA66B6EQ27325625-597F9659-0D71-41F1-8AFA-DE48EFCEA231Q27339258-073350A4-0322-424E-8BE4-FD0FF9F6709CQ27681463-5CDE2E85-42AC-4CE6-A1AB-44D435CA77D2Q27692111-04EC8C97-690F-46CD-8548-28825AAFE324Q28080628-EC95807C-3102-4EB6-94A3-6B64C1CF157CQ28115292-1E220309-5984-4D45-A3DD-86BD9B45821FQ28115639-8FA82472-926A-453F-8F6A-08BCB3D98868Q28237200-F201C5A9-B894-47EC-8B48-17F0DF6C9890Q28297716-4F30CF13-E9E1-41A2-AFD8-9DFB875E42E2Q30406158-524811F7-2B80-4B8A-9A8E-274384B4EE68Q30497589-DCE27F0E-328B-4184-A17E-B98E9D1BE2D1Q30537986-587DEAE8-9D77-4DAE-92A9-71D94314FCE7Q30541099-D3FA4D83-08B7-4E3F-9E61-9A047B9C0335Q30573122-795EF067-9020-4CA1-9C89-D074B2E1F784Q30574024-BA71C3F0-D4F7-40D4-B33C-35D7EEED607AQ30574944-AB416D0A-41E0-43F7-97B1-DA494ADEB18DQ30855394-A491AC20-A9CD-4670-9764-C9A12600D1C9Q33619521-ABFDAEE8-8D3D-4537-ADB1-BBF25E902088Q33631908-4FD7388A-1A4F-4167-B119-12E8160809EEQ33733914-001229C9-F07F-400F-8C7B-AB7E3186249EQ33746283-879C2BDE-E698-4F0B-BBAF-CC9927B2C316Q33763346-9191D765-F630-4B4B-8E6F-E30D0DAD3251Q33786698-EBC8AECF-058D-4C00-9B06-1BA6FFA305CFQ33849007-25A9495B-56DA-4B1E-A6FB-25437D678EB6Q33889532-BA03A0CB-68B4-4CD9-8CEB-90544C1BFE76Q33930825-D9ABA873-5058-430B-AEA7-63542F17B021Q34155410-A00DF19B-3808-45E8-9214-B75FD757639AQ34232143-E49D6375-E93A-40B2-B45B-D80ED4286007Q34285952-27A96D4B-8536-4F06-8946-325B420BFC0E
P2860
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@ast
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@en
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@nl
type
label
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@ast
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@en
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@nl
prefLabel
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@ast
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@en
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@nl
P2093
P2860
P356
P1476
ALS-associated mutations in TD ...... TDP-43 complexes with FUS/TLS.
@en
P2093
Claudio P Albuquerque
Don W Cleveland
Huilin Zhou
Joo Seok Han
Seiya Tokunaga
Shuo-Chien Ling
P2860
P304
13318-13323
P356
10.1073/PNAS.1008227107
P407
P577
2010-07-12T00:00:00Z