Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
about
The RAG1 N-terminal domain is an E3 ubiquitin ligaseA functional analysis of the spacer of V(D)J recombination signal sequencesDirect in vivo VH to JH rearrangement violating the 12/23 rule.Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisComputational tools for understanding sequence variability in recombination signalsPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemSingle-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsisThe taming of the shrew: Regulation of a catalytically active domesticated transposaseThermal dependency of RAG1 self-association properties.Initiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assemblyThe in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleRAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.Deletion of the RAG2 C terminus leads to impaired lymphoid development in miceInverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA.Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationGene segment selection in V(D)J recombination: accessibility and beyond.Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product releaseRegulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Single-molecule analysis of RAG-mediated V(D)J DNA cleavage.Requirements for DNA hairpin formation by RAG1/2Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.The bounty of RAGs: recombination signal complexes and reaction outcomes.How to keep V(D)J recombination under control.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesFluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.Turning T-cell receptor beta recombination on and off: more questions than answers.53BP1 facilitates long-range DNA end-joining during V(D)J recombination.Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2An activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cellsMolecular mechanism underlying RAG1/RAG2 synaptic complex formation.DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase.
P2860
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P2860
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Ordered assembly of the V
@nl
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@ast
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@en
type
label
Ordered assembly of the V
@nl
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@ast
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@en
prefLabel
Ordered assembly of the V
@nl
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@ast
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@en
P2860
P356
P1433
P1476
Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
@en
P2093
Jessica M Jones
Martin Gellert
P2860
P304
P356
10.1093/EMBOJ/CDF394
P407
P577
2002-08-01T00:00:00Z