Chk1 promotes replication fork progression by controlling replication initiation. - Wikidata - wikimedia - TriplyDB

Chk1 promotes replication fork progression by controlling replication initiation.

Chk1 promotes replication fork progression by controlling replication initiation.

http://www.wikidata.org/entity/Q34136566

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Targeting DNA Replication Stress for Cancer Therapy Activation of new replication foci under conditions of replication stress.Checkpoint kinase 1 in DNA damage response and cell cycle regulation The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design Roles of Chk1 in cell biology and cancer therapy DNA damage response genes and the development of cancer metastasis USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication USP7 is a SUMO deubiquitinase essential for DNA replication Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.RAD51AP1-deficiency in vertebrate cells impairs DNA replication.Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1 Replication fork integrity and intra-S phase checkpoint suppress gene amplification.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation Cdc45 is limiting for replication initiation in humans Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736 Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts The level of origin firing inversely affects the rate of replication fork progression.Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.

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P2860

Chk1 promotes replication fork progression by controlling replication initiation.

http://www.wikidata.org/entity/Q34136566

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Chk1 promotes replication fork progression by controlling replication initiation.

@ast

Chk1 promotes replication fork progression by controlling replication initiation.

@en

Chk1 promotes replication fork progression by controlling replication initiation.

@nl

type

label

Chk1 promotes replication fork progression by controlling replication initiation.

@ast

Chk1 promotes replication fork progression by controlling replication initiation.

@en

Chk1 promotes replication fork progression by controlling replication initiation.

@nl

prefLabel

Chk1 promotes replication fork progression by controlling replication initiation.

@ast

Chk1 promotes replication fork progression by controlling replication initiation.

@en

Chk1 promotes replication fork progression by controlling replication initiation.

@nl

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P356

PNAS.1005031107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Chk1 promotes replication fork progression by controlling replication initiation.

@en

P2093

Eva Petermann

http://www.w3.org/2001/XMLSchema#string

Mick Woodcock

http://www.w3.org/2001/XMLSchema#string

P2860

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Identification and characterization of a human protein kinase related to budding yeast Cdc7p

Claspin promotes normal replication fork rates in human cells

Cdc7-Dbf4 and the human S checkpoint response to UVC

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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16090-16095

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scholarly article

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10.1073/PNAS.1005031107

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P433

37

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P478

107

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Thomas Helleday

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2010-08-30T00:00:00Z

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46095417

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20805465

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2941317

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