The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.
about
Structure of the human histamine H1 receptor complex with doxepinInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATStructural basis for action by diverse antidepressants on biogenic amine transportersFrom linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter.Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.Empowering pharmacoinformatics by linked life science dataMutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelThe mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transportersMolecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.Identification of a novel selective serotonin reuptake inhibitor by coupling monoamine transporter-based virtual screening and rational molecular hybridizationIn silico modification of oseltamivir as neuraminidase inhibitor of influenza A virus subtype H1N1.Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.Monoamine transporters: vulnerable and vital doorkeepers.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.The solute carrier 6 family of transportersSteric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporterGenetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.Thermostabilisation of the serotonin transporter in a cocaine-bound conformation.Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding SitesDesign and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.New design strategies for antidepressant drugs.Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.(S)- and (R)-fluoxetine as native markers in mass spectrometry (MS) binding assays addressing the serotonin transporter.Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling.Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.
P2860
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P2860
The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The high-affinity binding site ...... of the serotonin transporter.
@ast
The high-affinity binding site ...... of the serotonin transporter.
@en
The high-affinity binding site ...... of the serotonin transporter.
@nl
type
label
The high-affinity binding site ...... of the serotonin transporter.
@ast
The high-affinity binding site ...... of the serotonin transporter.
@en
The high-affinity binding site ...... of the serotonin transporter.
@nl
prefLabel
The high-affinity binding site ...... of the serotonin transporter.
@ast
The high-affinity binding site ...... of the serotonin transporter.
@en
The high-affinity binding site ...... of the serotonin transporter.
@nl
P2860
P50
P356
P1476
The high-affinity binding site ...... of the serotonin transporter.
@en
P2093
Ilka Steiner
René Weissensteiner
P2860
P304
P356
10.1124/MOL.110.067538
P577
2010-09-09T00:00:00Z