Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter
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Monoamine transporters: insights from molecular dynamics simulationsDesigning modulators of monoamine transporters using virtual screening techniquesLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterDiscovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporterComputational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analoguesX-ray structures and mechanism of the human serotonin transporter.The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeNovel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.Chloride binding site of neurotransmitter sodium symporters.Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding SitesDesign and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporterImpact of disruption of secondary binding site S2 on dopamine transporter function.Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporterImportance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.Stereoselective inhibition of serotonin transporters by antimalarial compounds.Overview of Monoamine Transporters.Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.Structural basis for recognition of diverse antidepressants by the human serotonin transporter.Antidepressants at work
P2860
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P2860
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@ast
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@en
type
label
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@ast
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@en
prefLabel
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@ast
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@en
P2093
P2860
P356
P1476
Steric hindrance mutagenesis i ...... s to the serotonin transporter
@en
P2093
Claus J Loland
Harel Weinstein
Per Plenge
Thijs Beuming
Ulrik Gether
P2860
P304
39316-39326
P356
10.1074/JBC.M112.371765
P407
P577
2012-09-24T00:00:00Z