Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
about
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceCancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesisA genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancerAneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and humanGenetic and Chemical Models of Colorectal Cancer in Mice.Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.Mouse models of gastrointestinal tumors.Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesisDistinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer.Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivoLive bacteria as the basis for immunotherapies against cancer.Aberrant crypt foci as microscopic precursors of colorectal cancer.The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.Intestinal homeostasis and neoplasia studied using conditional transgenesis.Molecular Genetics of Colorectal Cancer: An OverviewNox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.Wnt-signaling and senescence: A tug of war in early neoplasia?PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulinIdentification of the MUC2 Promoter as a Strong Promoter for Intestinal Gene Expression through Generation of Transgenic Quail Expressing GFP in Gut Epithelial CellsRegulation of homeostasis and oncogenesis in the intestinal epithelium by Ras.Mechanisms of aneuploidy induction by RAS and RAF oncogenesRAS signalling in the colorectum in health and disease.Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-Displacement-protein (CUX1) repressor.Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice.Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells.Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development.Impact of GSTT1, GSTM1, GSTP1 and NAT2 genotypes on KRAS2 and TP53 gene mutations in colorectal cancer.
P2860
Q26795609-583BF0EC-37A1-45D1-97FF-7DB96E33C19CQ27307633-54704353-39AA-4423-88FC-49D5DCF98AD3Q27852431-77365032-9B0D-4311-91AF-AC11B4516F55Q28252635-EF1D922E-DBF7-418C-A1D3-9FDD7BE3187AQ28510491-C6777B12-110C-4390-B077-E3B420A84365Q33771627-98B1C850-F692-4534-8E1B-B97F389EF621Q33797492-7EEC5BBB-3E7B-49A4-8FFF-D3D4431077BAQ34328635-493AE6DE-45A9-4561-B97E-F9B3C3A04ED0Q34348666-3A3835DA-7C7C-439E-AC5B-7F09D1BDC9C1Q34516144-C35BFAF6-6502-4E44-94F9-8BEEC32EE4EEQ34585656-42C3F0DF-1FFB-4A01-AA84-9C19D027AEA2Q34637873-923EFE9C-13A2-49E3-BEBE-FFCC8535E402Q34989253-1D31B162-3047-4635-974C-CD060A82FA43Q35010156-6B5EE951-AA67-4536-B609-D048142E2E8BQ35080479-EB4241C6-9F36-4BB7-9910-85C425A07A89Q35193514-BDE58C2A-A5E8-450F-B4EE-E29AA7A3FEE3Q35605612-749F64E7-B1BE-4B20-AAD3-4AE0BAC56C7BQ36405466-DA4D8F34-3AC7-446B-AEF7-EDE454B1E382Q36542799-F18BA466-4F14-4A19-929A-531C4B571539Q36697241-C3C6DB99-09EE-48EE-956E-02A4B9BE503AQ36788490-1D577BBF-C963-48A9-BF6A-5286E0C612A4Q37004224-BE81A47C-9677-43A5-A83F-0880B5BAD0ACQ37173872-9EE6FFB5-F231-4ECD-93BC-F840C2D8D6E0Q37287025-05AACE64-1E0B-467B-92D1-54278C58FCA7Q37290922-21D157B4-B7AC-48B8-A02D-46A1C213B320Q37312050-41B4B3B1-D7DB-4E1B-A34A-C8C37CF7D501Q37631679-A75A4B0F-BAFD-482C-87D5-1F89185D781BQ37899488-3730BB75-8D54-4CE1-AC89-A4E572FEEE51Q37948057-3A781872-CCB0-4E00-8B9A-A2678DD10C50Q37974687-E97E6A5E-9F1D-4832-B00F-3DCB992E5BEEQ38271066-31FB9C3C-CA29-4987-990B-E7019EE877A0Q39644277-C54B7D87-026B-4BB2-996F-29B78227ECABQ39895829-FF9E84EA-CA85-41D7-BD5A-6A3D12950024Q40634782-F19F4904-32B1-4048-B651-9207D54EBF01Q40667540-B0114E33-E262-44CF-978B-891360B3FCD9Q41253339-1181BBFD-3E6C-4DE3-97BE-31CF72A263F9Q42877660-B9EAA49E-EBA3-40FC-A6C7-40E29EBEE5C0Q43274553-74AC7AF2-9D5D-4430-936F-5C0BEFA59D2DQ43297335-BDE5FD2D-A7A8-43B6-AF35-C53AA8E0A78BQ44834239-56E010A2-69CB-4FCD-A175-EC717045BF50
P2860
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@ast
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@en
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@nl
type
label
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@ast
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@en
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@nl
prefLabel
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@ast
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@en
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@nl
P2093
P356
P1433
P1476
Targeted expression of oncogen ...... taneous tumorigenesis in mice.
@en
P2093
Coralie Fouquet
Daniel Louvard
Daniel Pinto
Dany Rouillard
Fatima el-Marjou
Klaus-Peter Janssen
Sylvie Robine
Xavier Sastre
P304
P356
10.1053/GAST.2002.34786
P407
P577
2002-08-01T00:00:00Z