Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2 - Wikidata - wikimedia - TriplyDB

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

http://www.wikidata.org/entity/Q34282596

about

Histone H3 mutations--a special role for H3.3 in tumorigenesis?A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading Functionally defined therapeutic targets in diffuse intrinsic pontine glioma Histones: at the crossroads of peptide and protein chemistry.Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.Mutations in chromatin machinery and pediatric high-grade glioma Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy.Oncogenic Mechanisms of Histone H3 Mutations.Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children.Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma.Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells.Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Supple Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.Structure, mechanism, and regulation of polycomb repressive complex 2.ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference.Oncohistones: drivers of pediatric cancers.Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

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P2860

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

http://www.wikidata.org/entity/Q34282596

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

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prefLabel

Strategy for "detoxification" ...... ith the methyltransferase PRC2

@ast

Strategy for "detoxification" ...... ith the methyltransferase PRC2

@en

Strategy for "detoxification" ...... ith the methyltransferase PRC2

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Journal of the American Chemical Society

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Strategy for "detoxification" ...... ith the methyltransferase PRC2

@en

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C David Allis

http://www.w3.org/2001/XMLSchema#string

Manuel M Müller

http://www.w3.org/2001/XMLSchema#string

Tom W Muir

http://www.w3.org/2001/XMLSchema#string

Zachary Z Brown

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular architecture of human polycomb repressive complex 2

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Structure and catalytic mechanism of a SET domain protein methyltransferase

Role of the polycomb protein EED in the propagation of repressive histone marks

Histone methylation by PRC2 is inhibited by active chromatin marks

The language of covalent histone modifications

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

The Polycomb complex PRC2 and its mark in life

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13498-13501

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scholarly article

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10.1021/JA5060934

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39

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136

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Siddhant U Jain

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2014-09-19T00:00:00Z

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265256801

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25180930

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4183613

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