A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.
about
TA205, an anti-talin monoclonal antibody, inhibits integrin-talin interactionActivation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundleIntegrin bidirectional signaling: a molecular viewIntegrin-dependent activation of the JNK signaling pathway by mechanical stressStructural Determinants of Integrin Binding to the Talin RodStructure of a double ubiquitin-like domain in the talin head: a role in integrin activationRGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.New insights into vinculin function and regulation.An essential role for talin during alpha(M)beta(2)-mediated phagocytosisTalin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafishA talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.Structural and biophysical properties of the integrin-associated cytoskeletal protein talin.Mutations in the Drosophila alphaPS2 integrin subunit uncover new features of adhesion site assembly.Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.Mechanisms of talin-dependent integrin signaling and crosstalkQuantification of integrin receptor agonism by fluorescence lifetime imaging.Alternative mechanisms for talin to mediate integrin functionPharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus B19: improved ex vivo gene transfer to human erythroid progenitor cells.Talin - the master of integrin adhesions.Structural basis for the autoinhibition of talin in regulating integrin activation.The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.Multiple factors contribute to integrin-talin interactions in vivo.Vinculin regulates assembly of talin: β3 integrin complexes.
P2860
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P2860
A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A fluorescence cell biology ap ...... equence within the rod domain.
@ast
A fluorescence cell biology ap ...... equence within the rod domain.
@en
A fluorescence cell biology ap ...... equence within the rod domain.
@nl
type
label
A fluorescence cell biology ap ...... equence within the rod domain.
@ast
A fluorescence cell biology ap ...... equence within the rod domain.
@en
A fluorescence cell biology ap ...... equence within the rod domain.
@nl
prefLabel
A fluorescence cell biology ap ...... equence within the rod domain.
@ast
A fluorescence cell biology ap ...... equence within the rod domain.
@en
A fluorescence cell biology ap ...... equence within the rod domain.
@nl
P2093
P2860
P356
P1476
A fluorescence cell biology ap ...... equence within the rod domain.
@en
P2093
Chantal Melchior
Johan Hoebeke
Kenneth Takeda
Laurent Tremuth
Nelly Kieffer
Philippe Rondé
Stephanie Kreis
Sébastien Plançon
P2860
P304
22258-22266
P356
10.1074/JBC.M400947200
P407
P577
2004-03-18T00:00:00Z