The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.
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Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamicsVinculin controls talin engagement with the actomyosin machinery.The structure of the C-terminal actin-binding domain of talinStructural Determinants of Integrin Binding to the Talin RodStructure of a double ubiquitin-like domain in the talin head: a role in integrin activationCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinCrystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talinLoss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.Talin depletion reveals independence of initial cell spreading from integrin activation and traction.Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness.Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.Vinculin activation is necessary for complete talin bindingThe talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.Talin 2 is a large and complex gene encoding multiple transcripts and protein isoformsThe C terminus of talin links integrins to cell cycle progression.Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafishStructure and mechanics of integrin-based cell adhesion.Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.Structural and biophysical properties of the integrin-associated cytoskeletal protein talin.A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.Mechanisms of talin-dependent integrin signaling and crosstalkRestoring the biophysical properties of decellularized patches through recellularization.Alternative mechanisms for talin to mediate integrin functionTalin - the master of integrin adhesions.The integrin-talin complex under force.Vinculin regulates assembly of talin: β3 integrin complexes.Integrin Activation: Implications for Axon Regeneration.
P2860
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P2860
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@ast
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@en
The integrin binding site 2
@nl
type
label
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@ast
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@en
The integrin binding site 2
@nl
prefLabel
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@ast
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@en
The integrin binding site 2
@nl
P2093
P2860
P356
P1476
The integrin binding site 2 (I ...... subunits to the cytoskeleton.
@en
P2093
Corinne Kox
David R Critchley
Erik Goormaghtigh
Laurent Tremuth
Michèle Moes
Nelly Kieffer
Patrick P G van der Holst
Sophie Rodius
Stacey J Coleman
Susan J Monkley
P2860
P304
17280-17288
P356
10.1074/JBC.M611846200
P407
P577
2007-04-11T00:00:00Z