Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityCHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancerThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsChk1 and p21 cooperate to prevent apoptosis during DNA replication fork stressTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsEssential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesThe combined status of ATM and p53 link tumor development with therapeutic responseIrofulven induces replication-dependent CHK2 activation related to p53 statusTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorStructural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapyUbiquitylation, neddylation and the DNA damage responseMDC1 is coupled to activated CHK2 in mammalian DNA damage response pathwaysProfile of Tak Wah MakThe response to and repair of RAG-mediated DNA double-strand breaksEDD mediates DNA damage-induced activation of CHK2Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathwayRegulating mammalian checkpoints through Cdc25 inactivation.CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancerChk2 suppresses the oncogenic potential of DNA replication-associated DNA damageATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosisTumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cellsCEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombinationTopoisomerase levels determine chemotherapy responsein vitroandin vivoOncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsThe anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.Anti-cancer efficacy of nonthermal plasma dissolved in a liquid, liquid plasma in heterogeneous cancer cellsRole of the translocation partner in protection against AID-dependent chromosomal translocationsp53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signalingInactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest responserasiRNAs, DNA damage, and embryonic axis specification.Bmi1 regulates mitochondrial function and the DNA damage response pathwayMechanisms of chromosomal instability in melanoma.Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.
P2860
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P2860
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@ast
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@en
Chk2 is a tumor suppressor tha ...... ataxia telangiectasia mutated
@nl
type
label
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@ast
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@en
Chk2 is a tumor suppressor tha ...... ataxia telangiectasia mutated
@nl
prefLabel
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@ast
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@en
Chk2 is a tumor suppressor tha ...... ataxia telangiectasia mutated
@nl
P2093
P2860
P1476
Chk2 is a tumor suppressor tha ...... and an ATM-independent manner
@en
P2093
Alison Cheung
Andrew J Elia
Andrew Wakeham
Atsushi Hirao
Elisa De Stanchina
Gordon Duncan
Hitoshi Okada
Jorge A Wong
Penny A Jeggo
Pierre-Marie Girard
P2860
P304
P356
10.1128/MCB.22.18.6521-6532.2002
P407
P577
2002-09-01T00:00:00Z