Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.
about
Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variantsPurified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinityRetroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo.Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceSrc phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.IGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells.Syndromes associated with insulin resistance and acanthosis nigricans.Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey.Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutantMutant insulin receptors in syndromes of insulin resistance.Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistanceBiochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activationHypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli.The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium.Cysteine-524 is not the only residue involved in the formation of disulphide-bonded dimers of the insulin receptorMolecular defects of insulin/IGF-1 receptor transmembrane signaling.Structure and function of the insulin-like growth factor I receptor.Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene.
P2860
Q24308772-89697E15-917B-42CE-8DD6-A7432904D8A7Q24322837-44CE2557-2A10-49EB-8120-5935A1A9FCFBQ24794042-FF10E177-F944-48D5-BCF2-D4A996DEA473Q28512935-C9B90D37-A026-4CCA-ABCA-1D4208517A08Q30469710-CC236449-374A-4764-BA35-CA64248A816EQ31864236-46A1B588-DDDD-4BA2-B967-D29A12B2B4BEQ33599464-8D9C1668-BC0C-4A89-90C3-F8110EB9B84CQ34186045-F402704C-0B82-4208-BA09-601909447CFCQ35098025-C3F06568-3923-47DD-94FB-FA8957490F6CQ35497387-EF1B223D-B29A-4597-B3C0-AFCEB2943008Q35609525-3138415A-AD9D-417A-9B17-9E1B5E697238Q36025880-D3B611D6-8102-4C2D-91C6-1B8EDC5BD8D5Q36295758-8BEF88D2-6C5A-4ED2-AFFC-2C2D1AD1FE9EQ36795937-19DBF013-8D19-4186-8031-672D7E68724FQ37312433-D514EC90-94E7-4F2B-B794-860F1E76F242Q37367772-45CA834B-683A-4AC7-9391-E8D1FC8035C1Q37628816-603AEAE6-297F-45B3-9AEC-0FC5312ED702Q37640121-B1C4569B-8CE7-45C0-A3F4-988C6378EF7DQ38075845-77119A29-F91B-4E09-8B19-7196B3F4CBDAQ38303392-EA5B4D41-36F4-4EAB-A69E-6BC703B14EC1Q40821663-14F0F78B-D065-4326-AA1E-F371392267B8Q41727239-F7752101-9F74-486C-AF5A-B2ACE06F4775Q42139574-D682757F-DE26-489D-B2D7-B6F56D7BB9D4Q54125041-2DA82B00-426F-4A4F-AE76-6A14CC41C071
P2860
Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@en
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@nl
type
label
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@en
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@nl
prefLabel
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@en
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@nl
P2093
P2860
P356
P1476
Transdominant inhibition of ty ...... wth factor I hybrid receptors.
@en
P2093
B D Morrison
D A McClain
J E Pessin
J L Treadway
P2860
P304
P356
10.1073/PNAS.88.1.214
P407
P577
1991-01-01T00:00:00Z