Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
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KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent mannerNovel roles for hERG K(+) channels in cell proliferation and apoptosisMicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic heartsMolecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine MyocardiumFast erg K+ currents in rat embryonic serotonergic neuronesDifferential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics.Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-á-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2.Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.HERG1 channelopathiesOxidative modulation of voltage-gated potassium channels.Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsAlternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoformsDifferential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channelsIsoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.Multiple splicing defects caused by hERG splice site mutation 2592+1G>A associated with long QT syndrome.Cardiac T-Tubule Microanatomy and Function.hERG 1b is critical for human cardiac repolarizationProgesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domainSig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells.hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.Age-and sex-dependent mRNA expression of KCNQ1 and HERG in patients with long QT syndrome type 1 and 2.Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.The eag domain regulates hERG channel inactivation gating via a direct interaction.The hERG potassium channel as a therapeutic target.Dominant negative consequences of a hERG 1b-specific mutation associated with intrauterine fetal death.Cotranslational association of mRNA encoding subunits of heteromeric ion channels.hERG gating microdomains defined by S6 mutagenesis and molecular modeling.Ether-a-go-go-related gene potassium channels: what's all the buzz about?Molecular Basis of Functional Myocardial Potassium Channel Diversity.Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death.Recurrent intrauterine fetal loss due to near absence of HERG: clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation.Piceatannol, a derivative of resveratrol, moderately slows I(Na) inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domainPhysiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.Drug-induced hERG block and long QT syndrome.Potassium-channel mutations and cardiac arrhythmias--diagnosis and therapy.
P2860
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P2860
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@ast
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@en
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@nl
type
label
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@ast
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@en
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@nl
prefLabel
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@ast
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@en
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@nl
P2093
P356
P1476
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
@en
P2093
Elon C Roti Roti
Eugenia M C Jones
Gail A Robertson
Jinling Wang
Samantha A Delfosse
P304
44690-44694
P356
10.1074/JBC.M408344200
P407
P577
2004-08-10T00:00:00Z