Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.
about
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cellsHuman Mob proteins regulate the NDR1 and NDR2 serine-threonine kinasesAcetylation of HIV-1 integrase by p300 regulates viral integration.LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexesEarly steps of retrovirus replicative cycleContribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear importA novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.The cell cycle independence of HIV infections is not determined by known karyophilic viral elements.Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in MaturationAllosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturationA new class of multimerization selective inhibitors of HIV-1 integraseIdentification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integraseRetroviral DNA IntegrationBiochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.HIV-1 pre-integration complexes selectively target decondensed chromatin in the nuclear periphery.An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Capsid is a dominant determinant of retrovirus infectivity in nondividing cells.Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cellsKnockdown of the cellular protein LRPPRC attenuates HIV-1 infection.Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear importImpact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction.Nuclear import of viral DNA genomes.Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins.HIV infection of non-dividing cells: a divisive problem.Uneven genetic robustness of HIV-1 integrase.Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signalA hard way to the nucleusNuclear translocation as a novel target for anti-HIV drugs.Proteomic analysis of early HIV-1 nucleoprotein complexes.Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophagesIdentification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.Integrase, LEDGF/p75 and HIV replication.Nucleocapsid protein function in early infection processes.In vivo biotinylation and capture of HIV-1 matrix and integrase proteins.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsThe HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.
P2860
Q24304259-9ED8931C-58F3-4927-999C-4243A4EBEABAQ24324672-460C9614-6ADC-4090-A391-347023614826Q24532024-3F339AE6-7F15-40A0-B62B-008139FED396Q24562936-5BB376FA-663F-4C82-BCAC-243E504D6015Q24792862-B48818C2-934F-4DE2-AAB8-B75C1E94E730Q24814060-8B79971E-9728-4544-BDE6-DA06F7B082C3Q24815183-D3945BF2-6AB6-4DFB-A773-E8DDC0B79A29Q24816846-F9BCDE15-245A-45E6-B45D-ACB03EBF4A5DQ27321347-8E70EED8-602E-4B87-9888-FB5DCADC5C63Q27677515-8175FDE8-A313-4D57-86DA-84BA4B308B2AQ27683994-89690004-E2D3-4BCD-8B8D-C3860904D30DQ28263591-51F4CA21-F3A5-46FF-84D6-BF82D45A0886Q28282487-952E63DF-E5DA-4693-B6A5-CE34165C166EQ28596842-78177063-6AE9-4D5C-8521-674666384CD3Q30157084-AE1BCA97-DE41-4845-B9C1-FA881CCA8960Q33280633-52B35DCE-1DA7-47BD-8E7B-F0B9C9F047E7Q33325927-7FC6FE78-0329-4D57-86EF-818A595D22F3Q33342802-7CD156EA-BDFD-4ADA-A23C-7BD0B3AA0971Q33396954-9CC23BE3-2E53-4954-B235-A66A93C82FF4Q33782016-2F2C0FC8-E4E6-46D0-9A0A-FCEAF97D14EBQ34152408-619EC26E-E935-4A8A-893E-D1F0EE2B9B24Q34227319-6008B788-F590-4E14-8208-2201B835B276Q34342115-9F3D72AA-2C8F-467E-8F03-323C0BFE02E1Q34359748-FE8427DE-C1BE-4AA2-9DD8-D152837A571BQ34859768-3C6D0829-392D-4F13-8079-AC08EB485A92Q35092065-2E0EC130-94EE-4131-9D81-29961DF59060Q35101356-AC12C459-D0E9-4AAF-AD6F-784C58346509Q35127406-F1A4C5D7-FB98-422B-89B5-DEBA16E1F7B8Q35360391-C9879CB4-BBCD-44A4-A11B-D3C04B496234Q35575399-09D5983E-BD66-4E5F-A8C3-6CD3768B6461Q35926911-590C90FF-604B-406C-B3BB-9535B8CB0C02Q36066205-E1D3C038-F42C-4FB3-AE1B-CFF663067D6DQ36587864-7DA51234-6722-4EEC-B8B0-663546582204Q36944674-4D28AEBA-E29B-484A-BBD0-4C5110E1190CQ36974724-D2D0FAAB-1C45-495F-9400-2838D485A5A8Q37081043-C8D880F7-A10B-4284-88F6-F7B2A85D7054Q37086413-8B2F5E58-2D38-43F8-8498-E12EE29ECE63Q37215458-6BC184EF-973A-4BBD-BC41-F97CB07EE726Q37945179-4C4760DA-0A30-44E8-AF57-8CF262DB206CQ38003158-0F39E7E9-8747-43DB-8108-3DAD4E32E9B3
P2860
Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Nuclear localization of human ...... ation, not PIC nuclear import.
@ast
Nuclear localization of human ...... ation, not PIC nuclear import.
@en
Nuclear localization of human ...... ation, not PIC nuclear import.
@nl
type
label
Nuclear localization of human ...... ation, not PIC nuclear import.
@ast
Nuclear localization of human ...... ation, not PIC nuclear import.
@en
Nuclear localization of human ...... ation, not PIC nuclear import.
@nl
prefLabel
Nuclear localization of human ...... ation, not PIC nuclear import.
@ast
Nuclear localization of human ...... ation, not PIC nuclear import.
@en
Nuclear localization of human ...... ation, not PIC nuclear import.
@nl
P2093
P2860
P1433
P1476
Nuclear localization of human ...... ation, not PIC nuclear import.
@en
P2093
Alan Engelman
Eric Devroe
Hina Z Ghory
Richard Lu
P2860
P304
10598-10607
P356
10.1128/JVI.76.21.10598-10607.2002
P407
P577
2002-11-01T00:00:00Z